Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US and UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β (IL-1β), which can activate and recruit neutrophils, exacerbating injury. Mature IL-1β is formed by caspase-1, dependent...

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Veröffentlicht in:	Toxicology and applied pharmacology 2011-05, Vol.252 (3), p.289-297
Hauptverfasser:	Williams, C. David, Antoine, Daniel J., Shaw, Patrick J., Benson, Craig, Farhood, Anwar, Williams, Dominic P., Kanneganti, Thirumala-Devi, Park, B. Kevin, Jaeschke, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetaminophen - toxicity Acetaminophen hepatotoxicity ACETYLSALICYLIC ACID Alanine Transaminase - blood ANALGESICS ANIMALS ANTIPYRETICS Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY BODY FLUIDS BUILDUP CARBOXYLIC ACIDS Carrier Proteins - immunology Caspase 1 - blood CENTRAL NERVOUS SYSTEM AGENTS CENTRAL NERVOUS SYSTEM DEPRESSANTS Chemical and Drug Induced Liver Injury - immunology DAMAGE Damage associated molecular patterns DIGESTIVE SYSTEM DISEASES DNA DRUGS GENES GLANDS Glutathione - blood High mobility group box protein HMGB1 Protein - blood HYDROXY ACIDS Inflammasome Inflammasomes - immunology INFLAMMATION Inflammation - chemically induced Inflammation - immunology INJURIES KERATIN Keratin-18 - blood LEUKOCYTES LIVER Male MAMMALS MATERIALS Medical sciences MICE Mice, Inbred C57BL Mice, Knockout NECROSIS NEUTROPHILS Neutrophils - immunology NLR Family, Pyrin Domain-Containing 3 Protein NUCLEIC ACIDS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PATHOLOGICAL CHANGES PROTEINS RODENTS SCLEROPROTEINS Statistics, Nonparametric Sterile inflammation SYMPTOMS Toxicology VERTEBRATES
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