Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgM
We report the synthesis and in vitro evaluation of a multivalent homing device, a polymer which contains preordered pendant groups with dual specificity, a trisaccharide moiety, which is specific for the siglec CD22, and an antibody specific hapten, nitrophenol. The device efficiently attracts antih...
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| Veröffentlicht in: | Bioconjugate chemistry 2011-04, Vol.22 (4), p.546-550 |
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| container_end_page | 550 |
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| container_issue | 4 |
| container_start_page | 546 |
| container_title | Bioconjugate chemistry |
| container_volume | 22 |
| creator | Cui, Lina Kitov, Pavel I Completo, Gladys C Paulson, James C Bundle, David R |
| description | We report the synthesis and in vitro evaluation of a multivalent homing device, a polymer which contains preordered pendant groups with dual specificity, a trisaccharide moiety, which is specific for the siglec CD22, and an antibody specific hapten, nitrophenol. The device efficiently attracts antihapten IgM to the surface of human lymphoma B cells as well as to CD22-conjugated magnetic beads by mediating the formation of a ternary complex on the surface of the target. |
| doi_str_mv | 10.1021/bc100579d |
| format | Article |
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| ispartof | Bioconjugate chemistry, 2011-04, Vol.22 (4), p.546-550 |
| issn | 1043-1802 1520-4812 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Antigen-Antibody Complex - chemistry Antigen-Antibody Complex - immunology Cell Membrane - chemistry Cell Membrane - immunology Cells Chemical synthesis Haptens - immunology Humans Immunoglobulin M - chemistry Immunoglobulin M - immunology Immunoglobulins Ligands Lymphoma Lymphoma, B-Cell - chemistry Lymphoma, B-Cell - immunology Macromolecular Substances - chemical synthesis Macromolecular Substances - chemistry Macromolecular Substances - immunology Magnetics Membranes Microspheres Molecular structure Nitrophenols - chemistry Nitrophenols - immunology Polymers Sialic Acid Binding Ig-like Lectin 2 - chemistry Sialic Acid Binding Ig-like Lectin 2 - immunology Surface Properties |
| title | Supramolecular Complexing of Membane Siglec CD22 Mediated by a Polyvalent Heterobifunctional Ligand that Templates on IgM |
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