A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and Citrate Buffer

In the current study, the effect of metal ions in combination with buffers (citrate, acetate, pH 4.5) on the stability of aqueous solutions of oxytocin was investigated. Both monovalent metal ions (Na + and K + ) and divalent metal ions (Ca 2+ , Mg 2+ , and Zn 2+ ) were tested all as chloride salts....

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Veröffentlicht in:	The AAPS journal 2011-06, Vol.13 (2), p.284-290
Hauptverfasser:	Avanti, Christina, Amorij, Jean-Pierre, Setyaningsih, Dewi, Hawe, Andrea, Jiskoot, Wim, Visser, Jan, Kedrov, Alexej, Driessen, Arnold J. M., Hinrichs, Wouter L. J., Frijlink, Henderik W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Buffers Chromatography, High Pressure Liquid - methods Citrates - chemistry Drug Stability Drug Storage Metals - chemistry Oxytocics - administration & dosage Oxytocics - chemistry Oxytocin - administration & dosage Oxytocin - chemistry Pharmaceutical Solutions Pharmacology/Toxicology Pharmacy Research Article Temperature
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