Methotrexate Toxicity in Growing Long Bones of Young Rats : A Model for Studying Cancer Chemotherapy-Induced Bone Growth Defects in Children

The advancement and intensive use of chemotherapy in treating childhood cancers has led to a growing population of young cancer survivors who face increased bone health risks. However, the underlying mechanisms for chemotherapy-induced skeletal defects remain largely unclear. Methotrexate (MTX), the...

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Veröffentlicht in:	BioMed research international 2011-01, Vol.2011 (2011), p.1-8
Hauptverfasser:	Fan, Chiaming, Georgiou, Kristen R., King, Tristan J., Xian, Cory J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biomedical research Bone Development - drug effects Bone Diseases - chemically induced Bone marrow Cancer Care and treatment Chemotherapy Child Children Diagnosis Disease Models, Animal Dosage and administration Health aspects Humans Long bones Medical research Methotrexate Methotrexate - toxicity Neoplasms - drug therapy Physiological aspects Rats Review Studies
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