Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmogenic disease occurring in patients with a structurally normal heartthe disease is characterized by life-threatening arrhythmias elicited by stress and emotion. In 2001, the ryanodine receptor was identified as the...

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Veröffentlicht in:	Circulation research 2011-04, Vol.108 (7), p.871-883
Hauptverfasser:	Priori, Silvia G, Chen, S.R Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium - metabolism Calsequestrin - genetics Cardiac dysrhythmias Cardiology. Vascular system Emotions - physiology Fundamental and applied biological sciences. Psychology Heart Humans Medical sciences Mutation - genetics Ryanodine Receptor Calcium Release Channel - genetics Sarcoplasmic Reticulum - physiology Stress, Psychological - physiopathology Tachycardia, Ventricular - genetics Tachycardia, Ventricular - metabolism Tachycardia, Ventricular - physiopathology Vertebrates: cardiovascular system
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