Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

Highly Efficient Capture of Circulating Tumor Cells by Using Nanostructured Silicon Substrates with Integrated Chaotic Micromixers

Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody‐coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise)....

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Veröffentlicht in:Angewandte Chemie International Edition 2011-03, Vol.50 (13), p.3084-3088
Hauptverfasser: Wang, Shutao, Liu, Kan, Liu, Jian, Yu, Zeta T.-F., Xu, Xiaowen, Zhao, Libo, Lee, Tom, Lee, Eun Kyung, Reiss, Jean, Lee, Yi-Kuen, Chung, Leland W. K., Huang, Jiaoti, Rettig, Matthew, Seligson, David, Duraiswamy, Kumaran N., Shen, Clifton K.-F., Tseng, Hsian-Rong
Format: Artikel
Sprache:eng
Schlagworte:
Breast Neoplasms - blood
Breast Neoplasms - chemistry
Breast Neoplasms - pathology
cancer diagnosis
cell capture
circulating tumor cell
Complex Mixtures - chemistry
Equipment Design
Female
Humans
Male
microfluidics
Microfluidics - instrumentation
Microfluidics - methods
Molecular Imaging
nanostructured materials
Nanostructures - chemistry
Neoplastic Cells, Circulating - chemistry
Neoplastic Cells, Circulating - pathology
Prostatic Neoplasms - blood
Prostatic Neoplasms - chemistry
Prostatic Neoplasms - pathology
Silicon - chemistry
Surface Properties
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Beschreibung
Zusammenfassung:Finding a needle in a haystack: A new technology is demonstrated to enrich circulating tumor cells (CTCs) with high efficiency by integrating an antibody‐coated silicon nanopillar (SiNP, see picture; gray) substrate with an overlaid polydimethylsiloxane (PDMS) microfluidic chaotic mixer (turquoise). It shows significantly improved sensitivity in detecting rare CTCs from whole blood, thus providing an alternative for monitoring cancer progression.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201005853