4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells

There has been a steady rise in fatalities associated with thick melanomas (>4 mm). Although understanding of the biology of the disease has improved, effective treatment strategies for patients with advanced metastatic melanoma remain elusive. Therefore, more intensive testing of agents with the...

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Veröffentlicht in:	Biochemical pharmacology 2011-05, Vol.81 (10), p.1211-1218
Hauptverfasser:	Payton, Florastina, Bose, Rumu, Alworth, William L., Kumar, Addanki P., Ghosh, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Methylcatechol agar Antineoplastic Agents - pharmacology Apoptosis Biological and medical sciences Catechols - pharmacology cell cycle Cell Cycle - drug effects Cell cycle arrest Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects cell viability cytotoxicity Dermatology drugs fruits Humans Medical sciences melanocytes Melanoma Melanoma - metabolism Melanoma - pathology metabolites metastasis Neoplasm Metastasis oxidative stress patients Pharmacology. Drug treatments quercetin Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Skin Neoplasms - metabolism Skin Neoplasms - pathology Survival Tumors of the skin and soft tissue. Premalignant lesions
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