Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants
Microorganisms and their hosts communicate with each other through an array of signals. The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synth...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2011-04, Vol.108 (17), p.7253-7258 |
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| creator | Ortiz-Castro, Randy Diaz-Perez, Cesar Martinez-Trujillo, Miguel del Rio, Rosa E Campos-Garcia, Jesus Lopez-Bucio, Jose |
| description | Microorganisms and their hosts communicate with each other through an array of signals. The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synthesized by microorganisms with diverse and noteworthy activities. Here, we present genetic, chemical, and plant-growth data showing that in Pseudomonas aeruginosa, the LasI quorum-sensing (QS) system controls the production of three DKPs--namely, cyclo(L-Pro-L-Val), cyclo(L-Pro-L-Phe), and cyclo(L-Pro-L-Tyr)--that are involved in plant growth promotion by this bacterium. Analysis of all three bacterial DKPs in Arabidopsis thaliana seedlings provided detailed information indicative of an auxin-like activity, based on their efficacy at modulating root architecture, activation of auxin-regulated gene expression, and response of auxin-signaling mutants tir1, tir1 afb2 afb3, arf7, arf19, and arf7arf19. The observation that QS-regulated bacterial production of DKPs modulates auxin signaling and plant growth promotion establishes an important function for DKPs mediating prokaryote/eukaryote transkingdom signaling. |
| doi_str_mv | 10.1073/pnas.1006740108 |
| format | Article |
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The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synthesized by microorganisms with diverse and noteworthy activities. Here, we present genetic, chemical, and plant-growth data showing that in Pseudomonas aeruginosa, the LasI quorum-sensing (QS) system controls the production of three DKPs--namely, cyclo(L-Pro-L-Val), cyclo(L-Pro-L-Phe), and cyclo(L-Pro-L-Tyr)--that are involved in plant growth promotion by this bacterium. Analysis of all three bacterial DKPs in Arabidopsis thaliana seedlings provided detailed information indicative of an auxin-like activity, based on their efficacy at modulating root architecture, activation of auxin-regulated gene expression, and response of auxin-signaling mutants tir1, tir1 afb2 afb3, arf7, arf19, and arf7arf19. The observation that QS-regulated bacterial production of DKPs modulates auxin signaling and plant growth promotion establishes an important function for DKPs mediating prokaryote/eukaryote transkingdom signaling.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1006740108</identifier><identifier>PMID: 21482761</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; Auxins ; Bacteria ; Bacterial Proteins - chemistry ; Bacterial Proteins - pharmacology ; Biological Sciences ; Data processing ; diketopiperazines ; eukaryotic cells ; Flowers & plants ; Gene expression ; Gene expression regulation ; growth promotion ; Hormones ; hosts ; indole acetic acid ; Indoleacetic Acids - metabolism ; Microorganisms ; Molecules ; mutants ; Mutation ; Peptides ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - pharmacology ; Physiology ; plant development ; Plant growth ; Plant growth regulators ; Plant roots ; Plants ; Prokaryotes ; prokaryotic cells ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - chemistry ; quorum sensing ; Root growth ; Roots ; Seedlings ; Seedlings - genetics ; Seedlings - growth & development ; Signal Transduction - drug effects</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.7253-7258</ispartof><rights>Copyright © 1993-2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Apr 26, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-44fc230663694e747af22dd0f0abeeacbb0350289eb1acb5186cab1b044cc7553</citedby><cites>FETCH-LOGICAL-c521t-44fc230663694e747af22dd0f0abeeacbb0350289eb1acb5186cab1b044cc7553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/108/17.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41242162$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41242162$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21482761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortiz-Castro, Randy</creatorcontrib><creatorcontrib>Diaz-Perez, Cesar</creatorcontrib><creatorcontrib>Martinez-Trujillo, Miguel</creatorcontrib><creatorcontrib>del Rio, Rosa E</creatorcontrib><creatorcontrib>Campos-Garcia, Jesus</creatorcontrib><creatorcontrib>Lopez-Bucio, Jose</creatorcontrib><title>Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Microorganisms and their hosts communicate with each other through an array of signals. The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synthesized by microorganisms with diverse and noteworthy activities. Here, we present genetic, chemical, and plant-growth data showing that in Pseudomonas aeruginosa, the LasI quorum-sensing (QS) system controls the production of three DKPs--namely, cyclo(L-Pro-L-Val), cyclo(L-Pro-L-Phe), and cyclo(L-Pro-L-Tyr)--that are involved in plant growth promotion by this bacterium. Analysis of all three bacterial DKPs in Arabidopsis thaliana seedlings provided detailed information indicative of an auxin-like activity, based on their efficacy at modulating root architecture, activation of auxin-regulated gene expression, and response of auxin-signaling mutants tir1, tir1 afb2 afb3, arf7, arf19, and arf7arf19. The observation that QS-regulated bacterial production of DKPs modulates auxin signaling and plant growth promotion establishes an important function for DKPs mediating prokaryote/eukaryote transkingdom signaling.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>Auxins</subject><subject>Bacteria</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - pharmacology</subject><subject>Biological Sciences</subject><subject>Data processing</subject><subject>diketopiperazines</subject><subject>eukaryotic cells</subject><subject>Flowers & plants</subject><subject>Gene expression</subject><subject>Gene expression regulation</subject><subject>growth promotion</subject><subject>Hormones</subject><subject>hosts</subject><subject>indole acetic acid</subject><subject>Indoleacetic Acids - metabolism</subject><subject>Microorganisms</subject><subject>Molecules</subject><subject>mutants</subject><subject>Mutation</subject><subject>Peptides</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - pharmacology</subject><subject>Physiology</subject><subject>plant development</subject><subject>Plant growth</subject><subject>Plant growth regulators</subject><subject>Plant roots</subject><subject>Plants</subject><subject>Prokaryotes</subject><subject>prokaryotic cells</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - chemistry</subject><subject>quorum sensing</subject><subject>Root growth</subject><subject>Roots</subject><subject>Seedlings</subject><subject>Seedlings - genetics</subject><subject>Seedlings - growth & development</subject><subject>Signal Transduction - drug effects</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhzAmIuHAKHY8d27kgoYovqRIHWnG0HMfZesnGwU4K-9_jaJdd4MLJb-TfPM3MI-QphdcUJLsYB5OyAiE5UFD3yIpCTUvBa7hPVgAoS8WRn5FHKW0AoK4UPCRnSLlCKeiKfL2OZkjf_LBuw7ZIfj2YPhdFY5JrizBkYScXvekLu7N9aP3oxsm3LhU__HRbmPmnH4rM-Ds_7Yqsx94MU3pMHnSmT-7J4T0nN-_fXV9-LK8-f_h0-faqtBXSqeS8s8hACCZq7iSXpkNsW-jANM4Z2zTAKkBVu4bmqqJKWNPQBji3VlYVOydv9r7j3Gxda90wRdPrMfqtiTsdjNd__wz-Vq_DnWagOGUyG7w6GMTwfXZp0lufrOvzFi7MSdfIEKoM_5dUgqla5dNn8uU_5CbMMV92gTgiCrFAF3vIxpBSdN1xaAp6CVcv4epTuLnj-Z-7HvnfaWbgxQFYOk92SlOpJVYsE8_2xCZNIR4RTpEjFXhy6EzQZh190jdfEKgAoHU-vmC_AJphvuY</recordid><startdate>20110426</startdate><enddate>20110426</enddate><creator>Ortiz-Castro, Randy</creator><creator>Diaz-Perez, Cesar</creator><creator>Martinez-Trujillo, Miguel</creator><creator>del Rio, Rosa E</creator><creator>Campos-Garcia, Jesus</creator><creator>Lopez-Bucio, Jose</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110426</creationdate><title>Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants</title><author>Ortiz-Castro, Randy ; 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The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synthesized by microorganisms with diverse and noteworthy activities. Here, we present genetic, chemical, and plant-growth data showing that in Pseudomonas aeruginosa, the LasI quorum-sensing (QS) system controls the production of three DKPs--namely, cyclo(L-Pro-L-Val), cyclo(L-Pro-L-Phe), and cyclo(L-Pro-L-Tyr)--that are involved in plant growth promotion by this bacterium. Analysis of all three bacterial DKPs in Arabidopsis thaliana seedlings provided detailed information indicative of an auxin-like activity, based on their efficacy at modulating root architecture, activation of auxin-regulated gene expression, and response of auxin-signaling mutants tir1, tir1 afb2 afb3, arf7, arf19, and arf7arf19. The observation that QS-regulated bacterial production of DKPs modulates auxin signaling and plant growth promotion establishes an important function for DKPs mediating prokaryote/eukaryote transkingdom signaling.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>21482761</pmid><doi>10.1073/pnas.1006740108</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Auxins Bacteria Bacterial Proteins - chemistry Bacterial Proteins - pharmacology Biological Sciences Data processing diketopiperazines eukaryotic cells Flowers & plants Gene expression Gene expression regulation growth promotion Hormones hosts indole acetic acid Indoleacetic Acids - metabolism Microorganisms Molecules mutants Mutation Peptides Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Physiology plant development Plant growth Plant growth regulators Plant roots Plants Prokaryotes prokaryotic cells Pseudomonas aeruginosa Pseudomonas aeruginosa - chemistry quorum sensing Root growth Roots Seedlings Seedlings - genetics Seedlings - growth & development Signal Transduction - drug effects |
| title | Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants |
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