Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death
Whereas most febrile seizures (FSs) carry a benign outcome, a subpopulation of individuals with prolonged FSs are at risk for later temporal lobe epilepsy. Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis...
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Veröffentlicht in: | Annals of neurology 2004-11, Vol.56 (5), p.709-714 |
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description | Whereas most febrile seizures (FSs) carry a benign outcome, a subpopulation of individuals with prolonged FSs are at risk for later temporal lobe epilepsy. Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis in such individuals. Here, we used serial MRIs, obtained before and at several time points after experimental prolonged FSs, to determine the prevalence and distribution of signal changes on T2‐weighted images and to investigate the pathological substrates leading to these changes. Seventy‐five percent of immature rats with experimental prolonged FSs had abnormal T2 signal enhancement at 24 hours, and 87.5% at 8 days after the seizures. The altered T2 values involved the dorsal hippocampus (75%), the piriform cortex (87.5%), and the amygdala (25%). However, these changes were not accompanied by evidence of neuronal injury or death in these regions, as assessed using the Fluoro‐Jade method. Thus, experimental prolonged FSs lead to relatively frequent abnormal MRI signal in “temporal lobe” structures. Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. Ann Neurol 2004 |
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Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis in such individuals. Here, we used serial MRIs, obtained before and at several time points after experimental prolonged FSs, to determine the prevalence and distribution of signal changes on T2‐weighted images and to investigate the pathological substrates leading to these changes. Seventy‐five percent of immature rats with experimental prolonged FSs had abnormal T2 signal enhancement at 24 hours, and 87.5% at 8 days after the seizures. The altered T2 values involved the dorsal hippocampus (75%), the piriform cortex (87.5%), and the amygdala (25%). However, these changes were not accompanied by evidence of neuronal injury or death in these regions, as assessed using the Fluoro‐Jade method. Thus, experimental prolonged FSs lead to relatively frequent abnormal MRI signal in “temporal lobe” structures. Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. Ann Neurol 2004</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.20266</identifier><identifier>PMID: 15389889</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Brain Mapping ; Cell Death ; Disease Models, Animal ; Fluoresceins ; Fluorescent Dyes ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Medical sciences ; Nervous system ; Nervous system (semeiology, syndromes) ; Neurology ; Neurons - pathology ; Organ Specificity ; Organic Chemicals ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Sprague-Dawley ; Seizures, Febrile - pathology ; Seizures, Febrile - physiopathology ; Signal Transduction - physiology ; Time Factors</subject><ispartof>Annals of neurology, 2004-11, Vol.56 (5), p.709-714</ispartof><rights>Copyright © 2003 American Neurological Association</rights><rights>2005 INIST-CNRS</rights><rights>2004 American Neurological Association 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5396-fbd8ae2516fbfc06cf6a6a80901e8c02b23a64526ac6ec183c8f35654129a61a3</citedby><cites>FETCH-LOGICAL-c5396-fbd8ae2516fbfc06cf6a6a80901e8c02b23a64526ac6ec183c8f35654129a61a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.20266$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.20266$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16281685$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15389889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubé, Céline</creatorcontrib><creatorcontrib>Yu, Hon</creatorcontrib><creatorcontrib>Nalcioglu, Orhan</creatorcontrib><creatorcontrib>Baram, Tallie Z.</creatorcontrib><title>Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Whereas most febrile seizures (FSs) carry a benign outcome, a subpopulation of individuals with prolonged FSs are at risk for later temporal lobe epilepsy. Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis in such individuals. Here, we used serial MRIs, obtained before and at several time points after experimental prolonged FSs, to determine the prevalence and distribution of signal changes on T2‐weighted images and to investigate the pathological substrates leading to these changes. Seventy‐five percent of immature rats with experimental prolonged FSs had abnormal T2 signal enhancement at 24 hours, and 87.5% at 8 days after the seizures. The altered T2 values involved the dorsal hippocampus (75%), the piriform cortex (87.5%), and the amygdala (25%). However, these changes were not accompanied by evidence of neuronal injury or death in these regions, as assessed using the Fluoro‐Jade method. Thus, experimental prolonged FSs lead to relatively frequent abnormal MRI signal in “temporal lobe” structures. Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. Ann Neurol 2004</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cell Death</subject><subject>Disease Models, Animal</subject><subject>Fluoresceins</subject><subject>Fluorescent Dyes</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Organ Specificity</subject><subject>Organic Chemicals</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Seizures, Febrile - pathology</subject><subject>Seizures, Febrile - physiopathology</subject><subject>Signal Transduction - physiology</subject><subject>Time Factors</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1vEzEQBmALgWhoOfAH0F5A6mFbf-xOvBwqRVEplUqRQlF7s2adcWPY7AZ7l7b8ehwSWjigniyNH8-M9TL2SvADwbk8xBYPJJcAT9hIlErkWhbVUzbiCoq8FKrYYS9i_Mo5r0Dw52wnIV1pXY3Y1WcKHpvs4-w0Q9dTyOh2lUpLavtUdlQH31AWyf8cAsV32aRJiObZhcyiv26TufH9ohv6rKUhdOvCnLBf7LFnDptIL7fnLvvy_vhi-iE_-3RyOp2c5bZUFeSunmskWQpwtbMcrAME1LzigrTlspYKoSgloAWyQiurnSqhLISsEASqXXa06bsa6iXNbdo7YGNW6QsY7kyH3vx70_qFue5-GMV1wZVMDd5uG4Tu-0CxN0sfLTUNttQN0cCYyzSxehSKsdQgiiLB_Q20oYsxkLvfRnCzDsykwMzvwJJ9_ff6D3KbUAJvtgCjxcYFbK2PDw6kFqDL5A437ibldff_iWZyPvkzOt-88LGn2_sXGL6lP6txaS7PT8zVms4up2amfgHzpbxs</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Dubé, Céline</creator><creator>Yu, Hon</creator><creator>Nalcioglu, Orhan</creator><creator>Baram, Tallie Z.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200411</creationdate><title>Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death</title><author>Dubé, Céline ; Yu, Hon ; Nalcioglu, Orhan ; Baram, Tallie Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5396-fbd8ae2516fbfc06cf6a6a80901e8c02b23a64526ac6ec183c8f35654129a61a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cell Death</topic><topic>Disease Models, Animal</topic><topic>Fluoresceins</topic><topic>Fluorescent Dyes</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Organ Specificity</topic><topic>Organic Chemicals</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Seizures, Febrile - pathology</topic><topic>Seizures, Febrile - physiopathology</topic><topic>Signal Transduction - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubé, Céline</creatorcontrib><creatorcontrib>Yu, Hon</creatorcontrib><creatorcontrib>Nalcioglu, Orhan</creatorcontrib><creatorcontrib>Baram, Tallie Z.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubé, Céline</au><au>Yu, Hon</au><au>Nalcioglu, Orhan</au><au>Baram, Tallie Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2004-11</date><risdate>2004</risdate><volume>56</volume><issue>5</issue><spage>709</spage><epage>714</epage><pages>709-714</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Whereas most febrile seizures (FSs) carry a benign outcome, a subpopulation of individuals with prolonged FSs are at risk for later temporal lobe epilepsy. Signal changes on magnetic resonance imaging (MRI) may provide early markers for changes in neuronal integrity that may promote epileptogenesis in such individuals. Here, we used serial MRIs, obtained before and at several time points after experimental prolonged FSs, to determine the prevalence and distribution of signal changes on T2‐weighted images and to investigate the pathological substrates leading to these changes. Seventy‐five percent of immature rats with experimental prolonged FSs had abnormal T2 signal enhancement at 24 hours, and 87.5% at 8 days after the seizures. The altered T2 values involved the dorsal hippocampus (75%), the piriform cortex (87.5%), and the amygdala (25%). However, these changes were not accompanied by evidence of neuronal injury or death in these regions, as assessed using the Fluoro‐Jade method. Thus, experimental prolonged FSs lead to relatively frequent abnormal MRI signal in “temporal lobe” structures. Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. Ann Neurol 2004</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15389889</pmid><doi>10.1002/ana.20266</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Animals, Newborn Biological and medical sciences Brain Mapping Cell Death Disease Models, Animal Fluoresceins Fluorescent Dyes Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Medical sciences Nervous system Nervous system (semeiology, syndromes) Neurology Neurons - pathology Organ Specificity Organic Chemicals Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Sprague-Dawley Seizures, Febrile - pathology Seizures, Febrile - physiopathology Signal Transduction - physiology Time Factors |
title | Serial MRI after experimental febrile seizures: Altered T2 signal without neuronal death |
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