Fibulin-5: two for the price of one maintaining pelvic support
Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of th...
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| Veröffentlicht in: | The Journal of clinical investigation 2011-05, Vol.121 (5), p.1688-1691 |
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| container_title | The Journal of clinical investigation |
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| creator | Northington, Gina M |
| description | Pelvic organ prolapse (POP) is a disabling disorder in women characterized by a loss of pelvic floor support leading to the herniation of the uterus into or through the vagina. POP is a complex problem that likely involves multiple mechanisms, and available therapies are limited. In this issue of the JCI, Budatha et al. explore the dual role carried out by fibulin-5 in facilitating the assembly of normal elastic fibers and inhibiting MMP-9 activity, revealing a new mechanism critical to the maintenance of pelvic organ support. |
| doi_str_mv | 10.1172/jci57438 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biomedical research Disease Models, Animal Elastic Tissue - metabolism Elastin - chemistry Extracellular Matrix Proteins - metabolism Female Glycoproteins Humans Matrix Metalloproteinase 9 - metabolism Mice Mice, Transgenic Pelvic Floor - pathology Pelvic Organ Prolapse Pelvis Physiological aspects Prolapse Protein Structure, Tertiary Risk factors Tropoelastin - chemistry Vagina - pathology |
| title | Fibulin-5: two for the price of one maintaining pelvic support |
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