Protein Kinase A-mediated 14-3-3 Association Impedes Human Dapper1 to Promote Dishevelled Degradation

Wnt signaling regulates embryo development and tissue homeostasis, and its deregulation leads to an array of diseases, including cancer. Dapper1 has been shown to be a key negative regulator of Wnt signaling. However, its function and regulation remain poorly understood. In this study, we report tha...

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Veröffentlicht in:	The Journal of biological chemistry 2011-04, Vol.286 (17), p.14870-14880
Hauptverfasser:	Chen, Hua, Liu, Linhua, Ma, Benyu, Ma, Ting Martin, Hou, Jun-Jie, Xie, Guo-Ming, Wu, Wei, Yang, Fu-Quan, Chen, Ye-Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism 14–3-3 Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - metabolism Cell Line, Tumor Cell Proliferation Colon Cancer Colonic Neoplasms - pathology Cyclic AMP-Dependent Protein Kinases - metabolism Dapper1 Dishevelled Dishevelled Proteins Humans Nuclear Proteins - antagonists & inhibitors Nuclear Translocation Phosphoproteins - metabolism Phosphorylation Protein Binding - physiology Protein Kinase A (PKA) Signal Transduction Wnt Pathway Wnt Proteins - metabolism
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