Borrelia burgdorferi infection regulates CD1 expression in human cells and tissues via IL1-β

The appearance of group 1 CD1 proteins (CD1a, CD1b and CD1c) on maturing myeloid DC is a key event that converts myeloid DC to effective lipid APC. Here, we show that Borrelia burgdorferi, the causative agent of Lyme disease, triggers appearance of group 1 CD1 proteins at high density on the surface...

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Veröffentlicht in:	European journal of immunology 2011-03, Vol.41 (3), p.694-705
Hauptverfasser:	Yakimchuk, Konstantin, Roura-Mir, Carme, Magalhaes, Kelly G, de Jong, Annemieke, Kasmar, Anne G, Granter, Scott R, Budd, Ralph, Steere, Allen, Pena-Cruz, Victor, Kirschning, Carsten, Cheng, Tan-Yun, Moody, D. Branch
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD1 - metabolism Borrelia burgdorferi - immunology CD1 Dendritic Cells - immunology Erythema Chronicum Migrans - immunology Glycoproteins - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans IL‐1 In Vitro Techniques Interleukin-1beta - metabolism Lipids - immunology Lyme disease Lyme Disease - immunology Monocytes - drug effects Monocytes - immunology Recombinant Proteins - pharmacology Signal Transduction - immunology Skin - immunology T cells Toll-Like Receptor 2 - metabolism Up-Regulation
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