Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion
Objectives : To compare the effectiveness and tolerability of misoprostol as a cervical ripening agent in first trimester abortion through three different routes of administration before surgical evacuation (SE). Materials and Methods : It was a hospital based prospective randomized open labeled par...
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| Veröffentlicht in: | Indian journal of pharmacology 2011-03, Vol.43 (2), p.172-175 |
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| creator | Parveen, Shagufta Khateeb, Zaffar Abbas Mufti, S.M Shah, M.A Tandon, Vishal R Hakak, S Singh, Z Yasmeen, Shagufta Mir, Shakeel A Tabasum, Rehana Jan, Nasreen |
| description | Objectives : To compare the effectiveness and tolerability of
misoprostol as a cervical ripening agent in first trimester abortion
through three different routes of administration before surgical
evacuation (SE). Materials and Methods : It was a hospital based
prospective randomized open labeled parallel study. A total of 150
randomly selected married women were divided in three groups for
sublingual (S/L), vaginal and oral 400 μg of misoprostol single
dose administration. The drug was administered 3-4 h before SE in the
S/L and vaginal groups and 12 h before the procedure in the oral group.
Efficacy was assessed on the basis of time taken for ripening,
dilatation achieved, duration of the procedure, intra-operative blood
loss, and pain score. The tolerability was noted on the basis of side
effects. Results : The mean time taken for cervical ripening was less
in sublingual administration (3.7±1.2 hr) as compared to the
vaginal and oral routes. The S/L group had significant cervical
dilatation (P |
| doi_str_mv | 10.4103/0253-7613.77356 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3081456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A251986542</galeid><sourcerecordid>A251986542</sourcerecordid><originalsourceid>FETCH-LOGICAL-b563t-72723c84441b23d37c070cb6767df91e624b1f55d86c04759f6a5d3a5a0639f53</originalsourceid><addsrcrecordid>eNptksGP1CAUxonRuLOjZ2-G6MGLnYVSoL2YbCaummziRc-EUuiyaWGEdhL_e1-dtbpmQhPo4_dev_f6IfSKkl1FCbsiJWeFFJTtpGRcPEEb2jR1wSSnT9Fmvb1AlznfE3ivGvEcXZSUy1LwcoP8Po4HnXyOAUeH89wOPvSzHt7jo-59WA46dDgmPeARsEOKeYoD9gEbm47eQDz5gw2Qhl1M2PmUJzwlP9o82YR1G9PkY3iBnjk9ZPvyYd-i7zcfv-0_F7dfP33ZX98WLRdsKmQpS2bqqqpoW7KOSUMkMa2QQnauoVaUVUsd510tDKkkb5zQvGOaayJY4zjbog-nuoe5HW1nbJhAuzqAIJ1-qqi9enwT_J3q41ExUtMKNGzRu4cCKf6YoQkFfRs7DDrYOGdVC8lKTkUD5Jv_yPs4J5gZQFzWQnAiAXp7gno9WOWDi_BVs5RU11CmqQWvSqCKM1RvgwWJMVjnIfyI353hYXV29OZswtUpwcAPzMm6dSKUqMVLanGLWtyifnsJMl7_O8iV_2OevxpaH8E1diVM8lqtwTt4KCUVZ78ACvfUSg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>857866507</pqid></control><display><type>article</type><title>Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion</title><source>PubMed Central Open Access</source><source>Bioline International</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>EZB Electronic Journals Library</source><creator>Parveen, Shagufta ; Khateeb, Zaffar Abbas ; Mufti, S.M ; Shah, M.A ; Tandon, Vishal R ; Hakak, S ; Singh, Z ; Yasmeen, Shagufta ; Mir, Shakeel A ; Tabasum, Rehana ; Jan, Nasreen</creator><creatorcontrib>Parveen, Shagufta ; Khateeb, Zaffar Abbas ; Mufti, S.M ; Shah, M.A ; Tandon, Vishal R ; Hakak, S ; Singh, Z ; Yasmeen, Shagufta ; Mir, Shakeel A ; Tabasum, Rehana ; Jan, Nasreen</creatorcontrib><description>Objectives : To compare the effectiveness and tolerability of
misoprostol as a cervical ripening agent in first trimester abortion
through three different routes of administration before surgical
evacuation (SE). Materials and Methods : It was a hospital based
prospective randomized open labeled parallel study. A total of 150
randomly selected married women were divided in three groups for
sublingual (S/L), vaginal and oral 400 μg of misoprostol single
dose administration. The drug was administered 3-4 h before SE in the
S/L and vaginal groups and 12 h before the procedure in the oral group.
Efficacy was assessed on the basis of time taken for ripening,
dilatation achieved, duration of the procedure, intra-operative blood
loss, and pain score. The tolerability was noted on the basis of side
effects. Results : The mean time taken for cervical ripening was less
in sublingual administration (3.7±1.2 hr) as compared to the
vaginal and oral routes. The S/L group had significant cervical
dilatation (P<0.001) and the duration of SE was less as compared to
the vaginal and oral routes. However, the mean intraoperative blood
loss was more in sublingual as compared to the vaginal and oral groups.
The intra-operative pain score of the S/L group was significantly lower
(1.9±1.1, P<0.05) as compared to the vaginal (2.6±1.7) or
oral route (3.3±1.7). Loose motions and nausea/vomiting were more
with the S/L and oral routes while blood loss was more in the vaginal
route. Conclusion : Administration of misoprostol by the sublingual
route is better than the oral and vaginal routes for cervical ripening.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.77356</identifier><identifier>PMID: 21572652</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of Indian Pharmacological Society</publisher><subject>Abortion ; Analysis ; Cervical ripening, first trimester abortion, misoprostol, surgical evacuation ; Complications and side effects ; Dosage and administration ; Drug therapy ; Medical research ; Misoprostol ; Properties ; Studies</subject><ispartof>Indian journal of pharmacology, 2011-03, Vol.43 (2), p.172-175</ispartof><rights>Copyright 2011 Indian Journal of Pharmacology.</rights><rights>COPYRIGHT 2011 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Mar/Apr 2011</rights><rights>Copyright: © Indian Journal of Pharmacology 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b563t-72723c84441b23d37c070cb6767df91e624b1f55d86c04759f6a5d3a5a0639f53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081456/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081456/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784,79187</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21572652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parveen, Shagufta</creatorcontrib><creatorcontrib>Khateeb, Zaffar Abbas</creatorcontrib><creatorcontrib>Mufti, S.M</creatorcontrib><creatorcontrib>Shah, M.A</creatorcontrib><creatorcontrib>Tandon, Vishal R</creatorcontrib><creatorcontrib>Hakak, S</creatorcontrib><creatorcontrib>Singh, Z</creatorcontrib><creatorcontrib>Yasmeen, Shagufta</creatorcontrib><creatorcontrib>Mir, Shakeel A</creatorcontrib><creatorcontrib>Tabasum, Rehana</creatorcontrib><creatorcontrib>Jan, Nasreen</creatorcontrib><title>Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>Objectives : To compare the effectiveness and tolerability of
misoprostol as a cervical ripening agent in first trimester abortion
through three different routes of administration before surgical
evacuation (SE). Materials and Methods : It was a hospital based
prospective randomized open labeled parallel study. A total of 150
randomly selected married women were divided in three groups for
sublingual (S/L), vaginal and oral 400 μg of misoprostol single
dose administration. The drug was administered 3-4 h before SE in the
S/L and vaginal groups and 12 h before the procedure in the oral group.
Efficacy was assessed on the basis of time taken for ripening,
dilatation achieved, duration of the procedure, intra-operative blood
loss, and pain score. The tolerability was noted on the basis of side
effects. Results : The mean time taken for cervical ripening was less
in sublingual administration (3.7±1.2 hr) as compared to the
vaginal and oral routes. The S/L group had significant cervical
dilatation (P<0.001) and the duration of SE was less as compared to
the vaginal and oral routes. However, the mean intraoperative blood
loss was more in sublingual as compared to the vaginal and oral groups.
The intra-operative pain score of the S/L group was significantly lower
(1.9±1.1, P<0.05) as compared to the vaginal (2.6±1.7) or
oral route (3.3±1.7). Loose motions and nausea/vomiting were more
with the S/L and oral routes while blood loss was more in the vaginal
route. Conclusion : Administration of misoprostol by the sublingual
route is better than the oral and vaginal routes for cervical ripening.</description><subject>Abortion</subject><subject>Analysis</subject><subject>Cervical ripening, first trimester abortion, misoprostol, surgical evacuation</subject><subject>Complications and side effects</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Medical research</subject><subject>Misoprostol</subject><subject>Properties</subject><subject>Studies</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptksGP1CAUxonRuLOjZ2-G6MGLnYVSoL2YbCaummziRc-EUuiyaWGEdhL_e1-dtbpmQhPo4_dev_f6IfSKkl1FCbsiJWeFFJTtpGRcPEEb2jR1wSSnT9Fmvb1AlznfE3ivGvEcXZSUy1LwcoP8Po4HnXyOAUeH89wOPvSzHt7jo-59WA46dDgmPeARsEOKeYoD9gEbm47eQDz5gw2Qhl1M2PmUJzwlP9o82YR1G9PkY3iBnjk9ZPvyYd-i7zcfv-0_F7dfP33ZX98WLRdsKmQpS2bqqqpoW7KOSUMkMa2QQnauoVaUVUsd510tDKkkb5zQvGOaayJY4zjbog-nuoe5HW1nbJhAuzqAIJ1-qqi9enwT_J3q41ExUtMKNGzRu4cCKf6YoQkFfRs7DDrYOGdVC8lKTkUD5Jv_yPs4J5gZQFzWQnAiAXp7gno9WOWDi_BVs5RU11CmqQWvSqCKM1RvgwWJMVjnIfyI353hYXV29OZswtUpwcAPzMm6dSKUqMVLanGLWtyifnsJMl7_O8iV_2OevxpaH8E1diVM8lqtwTt4KCUVZ78ACvfUSg</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Parveen, Shagufta</creator><creator>Khateeb, Zaffar Abbas</creator><creator>Mufti, S.M</creator><creator>Shah, M.A</creator><creator>Tandon, Vishal R</creator><creator>Hakak, S</creator><creator>Singh, Z</creator><creator>Yasmeen, Shagufta</creator><creator>Mir, Shakeel A</creator><creator>Tabasum, Rehana</creator><creator>Jan, Nasreen</creator><general>Medknow Publications on behalf of Indian Pharmacological Society</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><general>Medknow Publications</general><scope>RBI</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110301</creationdate><title>Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion</title><author>Parveen, Shagufta ; Khateeb, Zaffar Abbas ; Mufti, S.M ; Shah, M.A ; Tandon, Vishal R ; Hakak, S ; Singh, Z ; Yasmeen, Shagufta ; Mir, Shakeel A ; Tabasum, Rehana ; Jan, Nasreen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b563t-72723c84441b23d37c070cb6767df91e624b1f55d86c04759f6a5d3a5a0639f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abortion</topic><topic>Analysis</topic><topic>Cervical ripening, first trimester abortion, misoprostol, surgical evacuation</topic><topic>Complications and side effects</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Medical research</topic><topic>Misoprostol</topic><topic>Properties</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parveen, Shagufta</creatorcontrib><creatorcontrib>Khateeb, Zaffar Abbas</creatorcontrib><creatorcontrib>Mufti, S.M</creatorcontrib><creatorcontrib>Shah, M.A</creatorcontrib><creatorcontrib>Tandon, Vishal R</creatorcontrib><creatorcontrib>Hakak, S</creatorcontrib><creatorcontrib>Singh, Z</creatorcontrib><creatorcontrib>Yasmeen, Shagufta</creatorcontrib><creatorcontrib>Mir, Shakeel A</creatorcontrib><creatorcontrib>Tabasum, Rehana</creatorcontrib><creatorcontrib>Jan, Nasreen</creatorcontrib><collection>Bioline International</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parveen, Shagufta</au><au>Khateeb, Zaffar Abbas</au><au>Mufti, S.M</au><au>Shah, M.A</au><au>Tandon, Vishal R</au><au>Hakak, S</au><au>Singh, Z</au><au>Yasmeen, Shagufta</au><au>Mir, Shakeel A</au><au>Tabasum, Rehana</au><au>Jan, Nasreen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion</atitle><jtitle>Indian journal of pharmacology</jtitle><addtitle>Indian J Pharmacol</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>43</volume><issue>2</issue><spage>172</spage><epage>175</epage><pages>172-175</pages><issn>0253-7613</issn><eissn>1998-3751</eissn><abstract>Objectives : To compare the effectiveness and tolerability of
misoprostol as a cervical ripening agent in first trimester abortion
through three different routes of administration before surgical
evacuation (SE). Materials and Methods : It was a hospital based
prospective randomized open labeled parallel study. A total of 150
randomly selected married women were divided in three groups for
sublingual (S/L), vaginal and oral 400 μg of misoprostol single
dose administration. The drug was administered 3-4 h before SE in the
S/L and vaginal groups and 12 h before the procedure in the oral group.
Efficacy was assessed on the basis of time taken for ripening,
dilatation achieved, duration of the procedure, intra-operative blood
loss, and pain score. The tolerability was noted on the basis of side
effects. Results : The mean time taken for cervical ripening was less
in sublingual administration (3.7±1.2 hr) as compared to the
vaginal and oral routes. The S/L group had significant cervical
dilatation (P<0.001) and the duration of SE was less as compared to
the vaginal and oral routes. However, the mean intraoperative blood
loss was more in sublingual as compared to the vaginal and oral groups.
The intra-operative pain score of the S/L group was significantly lower
(1.9±1.1, P<0.05) as compared to the vaginal (2.6±1.7) or
oral route (3.3±1.7). Loose motions and nausea/vomiting were more
with the S/L and oral routes while blood loss was more in the vaginal
route. Conclusion : Administration of misoprostol by the sublingual
route is better than the oral and vaginal routes for cervical ripening.</abstract><cop>India</cop><pub>Medknow Publications on behalf of Indian Pharmacological Society</pub><pmid>21572652</pmid><doi>10.4103/0253-7613.77356</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0253-7613 |
| ispartof | Indian journal of pharmacology, 2011-03, Vol.43 (2), p.172-175 |
| issn | 0253-7613 1998-3751 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3081456 |
| source | PubMed Central Open Access; Bioline International; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Abortion Analysis Cervical ripening, first trimester abortion, misoprostol, surgical evacuation Complications and side effects Dosage and administration Drug therapy Medical research Misoprostol Properties Studies |
| title | Comparison of sublingual, vaginal, and oral misoprostol in cervical ripening for first trimester abortion |
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