Pancreatic β-cell signaling: toward better understanding of diabetes and its treatment
Pancreatic β-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the β-cells and/or a decrease in the β-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus...
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| Veröffentlicht in: | Proceedings of the Japan Academy, Series B Series B, 2010/06/11, Vol.86(6), pp.563-577 |
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| container_title | Proceedings of the Japan Academy, Series B |
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| creator | SEINO, Susumu SHIBASAKI, Tadao MINAMI, Kohtaro |
| description | Pancreatic β-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the β-cells and/or a decrease in the β-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and β-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies. (Communicated by Hiroo IMURA, M.J.A.) |
| doi_str_mv | 10.2183/pjab.86.563 |
| format | Article |
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Jpn. Acad., Ser. B</addtitle><description>Pancreatic β-cells play a central role in the maintenance glucose homeostasis by secreting insulin, a key hormone that regulates blood glucose levels. Dysfunction of the β-cells and/or a decrease in the β-cell mass are associated closely with the pathogenesis and pathophysiology of diabetes mellitus, a major metabolic disease that is rapidly increasing worldwide. Clarification of the mechanisms of insulin secretion and β-cell fate provides a basis for the understanding of diabetes and its better treatment. In this review, we discuss cell signaling critical for the insulin secretory function based on our recent studies. 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| ispartof | Proceedings of the Japan Academy, Series B, 2010/06/11, Vol.86(6), pp.563-577 |
| issn | 0386-2208 1349-2896 |
| language | eng |
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| subjects | Animals cAMP cell signaling Cyclic AMP - metabolism Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diabetes Mellitus - therapy Epac2 Humans insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Pancreas, Exocrine - pathology pancreatic acinar cell Review Signal Transduction transdifferentiation |
| title | Pancreatic β-cell signaling: toward better understanding of diabetes and its treatment |
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