Role of conventional therapies in the era of biological treatment in Crohn’s disease
Outstanding progress regarding the pathophysiology of Crohn’s disease （CD） has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when avail...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2011-04, Vol.17 (14), p.1797-1806 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Gionchetti, Paolo Calabrese, Carlo Tambasco, Rosy Brugnera, Ramona Straforini, Giulia Liguori, Giuseppina Fornarini, Giulia Spuri Riso, Donatella Campieri, Massimo Rizzello, Fernando |
| description | Outstanding progress regarding the pathophysiology of Crohn’s disease （CD） has led to the development of innovative therapeutic concepts. Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when available,that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease and refractoriness to therapy increase. The advent of biological drugs has opened new therapeutic horizons for treating CD,modifying the treatment goals. However,the large majority of patients with CD will be managed through conventional therapy,even if they are a prelude to biological therapy. |
| doi_str_mv | 10.3748/wjg.v17.i14.1797 |
| format | Article |
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Numerous controlled trials have been performed in CD. This review concentrates on the results of randomized,placebo-controlled trials,and meta-analyses when available,that provide the highest degree of evidence. Current guidelines on the management of CD recommend a step-up approach to treatment involving the addition of more powerful therapies as the severity of disease and refractoriness to therapy increase. The advent of biological drugs has opened new therapeutic horizons for treating CD,modifying the treatment goals. However,the large majority of patients with CD will be managed through conventional therapy,even if they are a prelude to biological therapy.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v17.i14.1797</identifier><identifier>PMID: 21528051</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Co., Limited</publisher><subject>Crohn Disease - drug therapy ; Crohn Disease - physiopathology ; Crohn Disease - surgery ; Humans ; Meta-Analysis as Topic ; Placebos ; Randomized Controlled Trials as Topic ; Remission Induction ; Review ; 传统 ; 对照试验 ; 生物治疗 ; 生物药物 ; 疗法 ; 病理生理学 ; 耐火度</subject><ispartof>World journal of gastroenterology : WJG, 2011-04, Vol.17 (14), p.1797-1806</ispartof><rights>2011 Baishideng Publishing Group Co., Limited. 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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Crohn Disease - drug therapy Crohn Disease - physiopathology Crohn Disease - surgery Humans Meta-Analysis as Topic Placebos Randomized Controlled Trials as Topic Remission Induction Review 传统 对照试验 生物治疗 生物药物 疗法 病理生理学 耐火度 |
| title | Role of conventional therapies in the era of biological treatment in Crohn’s disease |
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