Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization
Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Design Prospective cohort study. Setting University in vitro fertilization (IVF) practice. Patient(s) A total of 102 women undergoing IVF. Intervention(s) Measurement of FFA...
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| Veröffentlicht in: | Fertility and sterility 2011-05, Vol.95 (6), p.1970-1974 |
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| container_title | Fertility and sterility |
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| creator | Jungheim, Emily S., M.D., M.S.C.I Macones, George A., M.D., M.S.C.E Odem, Randall R., M.D Patterson, Bruce W., Ph.D Lanzendorf, Susan E., Ph.D Ratts, Valerie S., M.D Moley, Kelle H., M.D |
| description | Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Design Prospective cohort study. Setting University in vitro fertilization (IVF) practice. Patient(s) A total of 102 women undergoing IVF. Intervention(s) Measurement of FFAs in serum and ovarian follicular fluid. Main Outcome Measure(s) Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology. Result(s) Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak ( r = 0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r = 0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs ≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n = 31) were more likely to have COCs with poor morphology than others (n = 71; OR 3.3, 95% CI1.2–9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β = 1.2; OR 3.4, 95% CI 1.1–10.4). Conclusion(s) Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility. |
| doi_str_mv | 10.1016/j.fertnstert.2011.01.154 |
| format | Article |
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Design Prospective cohort study. Setting University in vitro fertilization (IVF) practice. Patient(s) A total of 102 women undergoing IVF. Intervention(s) Measurement of FFAs in serum and ovarian follicular fluid. Main Outcome Measure(s) Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology. Result(s) Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak ( r = 0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r = 0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs ≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n = 31) were more likely to have COCs with poor morphology than others (n = 71; OR 3.3, 95% CI1.2–9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β = 1.2; OR 3.4, 95% CI 1.1–10.4). Conclusion(s) Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2011.01.154</identifier><identifier>PMID: 21353671</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Birth control ; blood serum ; body mass index ; Cell Shape ; Cohort Studies ; Cumulus Cells - cytology ; cumulus oocyte complex ; Fatty Acids, Nonesterified - analysis ; Fatty Acids, Nonesterified - blood ; Fatty Acids, Nonesterified - metabolism ; Female ; Fertilization in Vitro - methods ; follicular fluid ; Follicular Fluid - chemistry ; Follicular Fluid - metabolism ; free fatty acids ; Gynecology. Andrology. Obstetrics ; Humans ; in vitro fertilization ; Infertility - blood ; Infertility - complications ; Infertility - metabolism ; Infertility - therapy ; Internal Medicine ; Male ; Medical sciences ; Obesity - blood ; Obesity - complications ; Obesity - metabolism ; Obstetrics and Gynecology ; Oocyte ; oocytes ; Oocytes - cytology ; ovarian follicle ; Ovary - physiology ; patients ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - metabolism ; stearic acid ; Sterility. Assisted procreation ; women</subject><ispartof>Fertility and sterility, 2011-05, Vol.95 (6), p.1970-1974</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-70eb2541d62d30f73cc06c16e52aac177ac3c142bf26b9d96c2e92cb223a30d43</citedby><cites>FETCH-LOGICAL-c653t-70eb2541d62d30f73cc06c16e52aac177ac3c142bf26b9d96c2e92cb223a30d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2011.01.154$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24163198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21353671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jungheim, Emily S., M.D., M.S.C.I</creatorcontrib><creatorcontrib>Macones, George A., M.D., M.S.C.E</creatorcontrib><creatorcontrib>Odem, Randall R., M.D</creatorcontrib><creatorcontrib>Patterson, Bruce W., Ph.D</creatorcontrib><creatorcontrib>Lanzendorf, Susan E., Ph.D</creatorcontrib><creatorcontrib>Ratts, Valerie S., M.D</creatorcontrib><creatorcontrib>Moley, Kelle H., M.D</creatorcontrib><title>Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Design Prospective cohort study. Setting University in vitro fertilization (IVF) practice. Patient(s) A total of 102 women undergoing IVF. Intervention(s) Measurement of FFAs in serum and ovarian follicular fluid. Main Outcome Measure(s) Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology. Result(s) Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak ( r = 0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r = 0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs ≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n = 31) were more likely to have COCs with poor morphology than others (n = 71; OR 3.3, 95% CI1.2–9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β = 1.2; OR 3.4, 95% CI 1.1–10.4). Conclusion(s) Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>blood serum</subject><subject>body mass index</subject><subject>Cell Shape</subject><subject>Cohort Studies</subject><subject>Cumulus Cells - cytology</subject><subject>cumulus oocyte complex</subject><subject>Fatty Acids, Nonesterified - analysis</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>follicular fluid</subject><subject>Follicular Fluid - chemistry</subject><subject>Follicular Fluid - metabolism</subject><subject>free fatty acids</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>in vitro fertilization</subject><subject>Infertility - blood</subject><subject>Infertility - complications</subject><subject>Infertility - metabolism</subject><subject>Infertility - therapy</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - metabolism</subject><subject>Obstetrics and Gynecology</subject><subject>Oocyte</subject><subject>oocytes</subject><subject>Oocytes - cytology</subject><subject>ovarian follicle</subject><subject>Ovary - physiology</subject><subject>patients</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>stearic acid</subject><subject>Sterility. Assisted procreation</subject><subject>women</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk-P0zAQxSMEYpfCVwBfEBdaPHbitJeVlhX_pJU4LHu2nMmk65LYxXYKhS-PQ8sucOLiHPyb957zpigY8AVwUK82i45CcjHlcyE4wILDAqryXnEKVaXmlark_eKUc6jmXCzFSfEoxg3nXEEtHhYnAmQlVQ2nxY_zGD1ak6x3kTWUvhI51gUi1pmU9sygbeNLhuMw9mNk3uM-EUM_bHv6xgYftje-9-sMupb5nQnW5PnR4aTI2jFYt2bWsZ1NwbMptu3t919-j4sHnekjPTl-Z8X12zefLt7PLz---3BxfjnH_Iw0rzk1oiqhVaKVvKslIlcIiiphDEJdG5QIpWg6oZpVu1IoaCWwEUIaydtSzoqzg-52bAZqkVwKptfbYAcT9tobq_--cfZGr_1OS77kpYQs8OIoEPyXkWLSg41IfW8c-THqpZKlqGQ2nBXLA4nBxxiou3UBrqfq9EbfVaen6jQHnavLo0__THk7-LurDDw_Aiai6btgHNp4x5WgJKyWmXt24DrjtVmHzFxfZacqr4OolVKZeH0gKP_1naWgI1pySK0NhEm33v5P3rN_RLC3zuZkn2lPcePH4HKrGnQUmuuraRmnXQTgXEjJ5U86Bt9o</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Jungheim, Emily S., M.D., M.S.C.I</creator><creator>Macones, George A., M.D., M.S.C.E</creator><creator>Odem, Randall R., M.D</creator><creator>Patterson, Bruce W., Ph.D</creator><creator>Lanzendorf, Susan E., Ph.D</creator><creator>Ratts, Valerie S., M.D</creator><creator>Moley, Kelle H., M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization</title><author>Jungheim, Emily S., M.D., M.S.C.I ; Macones, George A., M.D., M.S.C.E ; Odem, Randall R., M.D ; Patterson, Bruce W., Ph.D ; Lanzendorf, Susan E., Ph.D ; Ratts, Valerie S., M.D ; Moley, Kelle H., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-70eb2541d62d30f73cc06c16e52aac177ac3c142bf26b9d96c2e92cb223a30d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>blood serum</topic><topic>body mass index</topic><topic>Cell Shape</topic><topic>Cohort Studies</topic><topic>Cumulus Cells - cytology</topic><topic>cumulus oocyte complex</topic><topic>Fatty Acids, Nonesterified - analysis</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>follicular fluid</topic><topic>Follicular Fluid - chemistry</topic><topic>Follicular Fluid - metabolism</topic><topic>free fatty acids</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>in vitro fertilization</topic><topic>Infertility - blood</topic><topic>Infertility - complications</topic><topic>Infertility - metabolism</topic><topic>Infertility - therapy</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - metabolism</topic><topic>Obstetrics and Gynecology</topic><topic>Oocyte</topic><topic>oocytes</topic><topic>Oocytes - cytology</topic><topic>ovarian follicle</topic><topic>Ovary - physiology</topic><topic>patients</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>stearic acid</topic><topic>Sterility. Assisted procreation</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jungheim, Emily S., M.D., M.S.C.I</creatorcontrib><creatorcontrib>Macones, George A., M.D., M.S.C.E</creatorcontrib><creatorcontrib>Odem, Randall R., M.D</creatorcontrib><creatorcontrib>Patterson, Bruce W., Ph.D</creatorcontrib><creatorcontrib>Lanzendorf, Susan E., Ph.D</creatorcontrib><creatorcontrib>Ratts, Valerie S., M.D</creatorcontrib><creatorcontrib>Moley, Kelle H., M.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jungheim, Emily S., M.D., M.S.C.I</au><au>Macones, George A., M.D., M.S.C.E</au><au>Odem, Randall R., M.D</au><au>Patterson, Bruce W., Ph.D</au><au>Lanzendorf, Susan E., Ph.D</au><au>Ratts, Valerie S., M.D</au><au>Moley, Kelle H., M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>95</volume><issue>6</issue><spage>1970</spage><epage>1974</epage><pages>1970-1974</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Design Prospective cohort study. Setting University in vitro fertilization (IVF) practice. Patient(s) A total of 102 women undergoing IVF. Intervention(s) Measurement of FFAs in serum and ovarian follicular fluid. Main Outcome Measure(s) Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology. Result(s) Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak ( r = 0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r = 0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs ≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n = 31) were more likely to have COCs with poor morphology than others (n = 71; OR 3.3, 95% CI1.2–9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β = 1.2; OR 3.4, 95% CI 1.1–10.4). Conclusion(s) Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21353671</pmid><doi>10.1016/j.fertnstert.2011.01.154</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Birth control blood serum body mass index Cell Shape Cohort Studies Cumulus Cells - cytology cumulus oocyte complex Fatty Acids, Nonesterified - analysis Fatty Acids, Nonesterified - blood Fatty Acids, Nonesterified - metabolism Female Fertilization in Vitro - methods follicular fluid Follicular Fluid - chemistry Follicular Fluid - metabolism free fatty acids Gynecology. Andrology. Obstetrics Humans in vitro fertilization Infertility - blood Infertility - complications Infertility - metabolism Infertility - therapy Internal Medicine Male Medical sciences Obesity - blood Obesity - complications Obesity - metabolism Obstetrics and Gynecology Oocyte oocytes Oocytes - cytology ovarian follicle Ovary - physiology patients Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - metabolism stearic acid Sterility. Assisted procreation women |
| title | Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization |
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