A novel assay for the DNA strand-transfer reaction of HIV-1 integrase

An essential step in the replication of retroviruses is the integration of a DNA copy of the viral genome into the genome of the host cell. Integration involves a series of well defined DNA cleavage and strand-transfer steps that are catalyzed by the virally encoded enzyme integrase (1-4). The seque...

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Veröffentlicht in:	Nucleic acids research 1994-03, Vol.22 (6), p.1121-1122
Hauptverfasser:	Hazuda, Daria J., Hastings, Jeffrey C., Wolfe, Abigail L., Emini, Emilio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Base Sequence Biological and medical sciences Deoxyribonuclease I - metabolism DNA - chemistry DNA - metabolism DNA Nucleotidyltransferases - metabolism Escherichia coli - enzymology Fundamental and applied biological sciences. Psychology HIV-1 - enzymology Human immunodeficiency virus 1 Integrases Microbiology Molecular Sequence Data Morphology, structure, chemical composition, physicochemical properties Repetitive Sequences, Nucleic Acid Substrate Specificity Virology
Online-Zugang:	Volltext
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