Neurobiological effects of sphingosine 1‐phosphate receptor modulation in the cuprizone model

ABSTRACT Fingolimod (FTY720) is a sphingosine 1‐phosphate (S1P) receptor modulator that regulates lymphocyte trafficking and exerts pleiotropic actions on oligodendrocytes (OLGs) and other neural cells. The purpose of this study was to investigate the role of S1P receptors in a non‐T‐cell model of d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2011-05, Vol.25 (5), p.1509-1518
Hauptverfasser:	Kim, Hye Jung, Miron, Veronique E., Dukala, Danuta, Proia, Richard L., Ludwin, Samuel K., Traka, Maria, Antel, Jack P., Soliven, Betty
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - metabolism Blotting, Western Corpus Callosum - cytology Corpus Callosum - drug effects Corpus Callosum - metabolism Cuprizone - toxicity Demyelinating Diseases - chemically induced Demyelinating Diseases - drug therapy demyelination fingolimod Fingolimod Hydrochloride FTY720 Immunohistochemistry Immunosuppressive Agents - pharmacology Interleukin-1beta - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron multiple sclerosis Myelin Sheath - drug effects Myelin Sheath - metabolism oligodendrocytes Oligodendroglia - drug effects Oligodendroglia - metabolism Propylene Glycols - pharmacology Propylene Glycols - therapeutic use Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism remyelination Research Communications Reverse Transcriptase Polymerase Chain Reaction Sphingosine - analogs & derivatives Sphingosine - pharmacology Sphingosine - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!