Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes
Abstract Genes for the fatty acid binding proteins (FABP) family encode small 14–15 kDa cytosolic proteins and can be regulated during type 2 diabetes mellitus (T2DM) and obesity. This study compared association of single nucleotide polymorphisms (SNPs) in FABP1-5 with T2DM in different ethnic group...
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| Veröffentlicht in: | Diabetes research and clinical practice 2011-04, Vol.92 (1), p.82-91 |
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| creator | Bu, Liming Salto, Lorena M De Leon, Kevin J De Leon, Marino |
| description | Abstract Genes for the fatty acid binding proteins (FABP) family encode small 14–15 kDa cytosolic proteins and can be regulated during type 2 diabetes mellitus (T2DM) and obesity. This study compared association of single nucleotide polymorphisms (SNPs) in FABP1-5 with T2DM in different ethnic groups. Associations with T2DM of SNPs in these proteins were assessed in African American (AA), non-Hispanic White (NHW), and Hispanic American (HA) individuals. A total of 650 DNA samples were genotyped; control samples were obtained from Coriell's North American Human Variation Panel Repository (NAHVP) of apparently healthy individuals and T2DM cases were taken from the American Diabetes Association GENNID Study. The rs454550 SNP of FABP5 showed a significant association with T2DM in NHW (OR: 9.03, 95% CI: 1.13–71.73, p = 0.014). Our analysis also identified a new FABP5 SNP (nSNP) that showed a significant association with T2DM in NHW (OR: 0.44, 95% CI: 0.19–0.99, p = 0.045) and AA (OR: 0.17, 95% CI: 0.03–0.80, p = 0.016). The Ala54Thr FABP2 polymorphism was significantly associated with T2DM in HA individuals only (OR: 1.85, 95% CI: 1.05–3.27, p = 0.032). All other FABP SNPs did not show association with T2DM. These findings suggest a potential distinct role(s) of SNPs in FABP5 and FABP2 genes in T2DM in different populations. |
| doi_str_mv | 10.1016/j.diabres.2011.01.005 |
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This study compared association of single nucleotide polymorphisms (SNPs) in FABP1-5 with T2DM in different ethnic groups. Associations with T2DM of SNPs in these proteins were assessed in African American (AA), non-Hispanic White (NHW), and Hispanic American (HA) individuals. A total of 650 DNA samples were genotyped; control samples were obtained from Coriell's North American Human Variation Panel Repository (NAHVP) of apparently healthy individuals and T2DM cases were taken from the American Diabetes Association GENNID Study. The rs454550 SNP of FABP5 showed a significant association with T2DM in NHW (OR: 9.03, 95% CI: 1.13–71.73, p = 0.014). Our analysis also identified a new FABP5 SNP (nSNP) that showed a significant association with T2DM in NHW (OR: 0.44, 95% CI: 0.19–0.99, p = 0.045) and AA (OR: 0.17, 95% CI: 0.03–0.80, p = 0.016). The Ala54Thr FABP2 polymorphism was significantly associated with T2DM in HA individuals only (OR: 1.85, 95% CI: 1.05–3.27, p = 0.032). All other FABP SNPs did not show association with T2DM. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-1100f589d587986f4c1f8cc70a9ec7d02ef2b1a000b9d4faa9307a69afd63c1b3</citedby><cites>FETCH-LOGICAL-c521t-1100f589d587986f4c1f8cc70a9ec7d02ef2b1a000b9d4faa9307a69afd63c1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.diabres.2011.01.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21288588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bu, Liming</creatorcontrib><creatorcontrib>Salto, Lorena M</creatorcontrib><creatorcontrib>De Leon, Kevin J</creatorcontrib><creatorcontrib>De Leon, Marino</creatorcontrib><title>Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Genes for the fatty acid binding proteins (FABP) family encode small 14–15 kDa cytosolic proteins and can be regulated during type 2 diabetes mellitus (T2DM) and obesity. This study compared association of single nucleotide polymorphisms (SNPs) in FABP1-5 with T2DM in different ethnic groups. Associations with T2DM of SNPs in these proteins were assessed in African American (AA), non-Hispanic White (NHW), and Hispanic American (HA) individuals. A total of 650 DNA samples were genotyped; control samples were obtained from Coriell's North American Human Variation Panel Repository (NAHVP) of apparently healthy individuals and T2DM cases were taken from the American Diabetes Association GENNID Study. The rs454550 SNP of FABP5 showed a significant association with T2DM in NHW (OR: 9.03, 95% CI: 1.13–71.73, p = 0.014). Our analysis also identified a new FABP5 SNP (nSNP) that showed a significant association with T2DM in NHW (OR: 0.44, 95% CI: 0.19–0.99, p = 0.045) and AA (OR: 0.17, 95% CI: 0.03–0.80, p = 0.016). The Ala54Thr FABP2 polymorphism was significantly associated with T2DM in HA individuals only (OR: 1.85, 95% CI: 1.05–3.27, p = 0.032). All other FABP SNPs did not show association with T2DM. These findings suggest a potential distinct role(s) of SNPs in FABP5 and FABP2 genes in T2DM in different populations.</description><subject>Adult</subject><subject>Aged</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endocrinology & Metabolism</subject><subject>Fatty acid binding protein (FABP)</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Single nucleotide polymorphism (SNP)</subject><subject>Type 2 diabetes mellitus (T2DM)</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUl1rFDEUDaLYtfoTlLz5tOtN5ivzUpFSP6BgofU5ZJI73awzyZhkW-bfm-muRX0pXLiBe3LO4Z5LyFsGGwas_rDbGKu6gHHDgbEN5ILqGVkx0fC14Lx5TlYZJx7eJ-RVjDsAqIuyeklOOONCVEKsyPWVH-bRh2lr4xipdbRXKc1UaWtoZ52x7pZOwSfMo4rGrb-nKkavrUrWO3pv05ameULK6WIIE8bX5EWvhohvjv2U_Ph8cXP-dX35_cu380-Xa11xltaMAfSVaE0lmlbUfalZL7RuQLWoGwMce94xlV13rSl7pdoCGlW3qjd1oVlXnJKzA--070Y0Gl0KapBTsKMKs_TKyn8nzm7lrb-TmUe0TZUJ3h8Jgv-1x5jkaKPGYVAO_T5KUfMaClZCRlYHpA4-xoD9owoDueQhd_KYh1zykJALFoV3f1t8_PUngAz4eABgXtSdxSCjtug0GhtQJ2m8fVLi7D8GPVhntRp-4oxx5_fB5RQkk5FLkNfLUSw3saw_H0RZ_AYckbVS</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Bu, Liming</creator><creator>Salto, Lorena M</creator><creator>De Leon, Kevin J</creator><creator>De Leon, Marino</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes</title><author>Bu, Liming ; Salto, Lorena M ; De Leon, Kevin J ; De Leon, Marino</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-1100f589d587986f4c1f8cc70a9ec7d02ef2b1a000b9d4faa9307a69afd63c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endocrinology & Metabolism</topic><topic>Fatty acid binding protein (FABP)</topic><topic>Fatty Acid-Binding Proteins - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Single nucleotide polymorphism (SNP)</topic><topic>Type 2 diabetes mellitus (T2DM)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bu, Liming</creatorcontrib><creatorcontrib>Salto, Lorena M</creatorcontrib><creatorcontrib>De Leon, Kevin J</creatorcontrib><creatorcontrib>De Leon, Marino</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bu, Liming</au><au>Salto, Lorena M</au><au>De Leon, Kevin J</au><au>De Leon, Marino</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>92</volume><issue>1</issue><spage>82</spage><epage>91</epage><pages>82-91</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Genes for the fatty acid binding proteins (FABP) family encode small 14–15 kDa cytosolic proteins and can be regulated during type 2 diabetes mellitus (T2DM) and obesity. This study compared association of single nucleotide polymorphisms (SNPs) in FABP1-5 with T2DM in different ethnic groups. Associations with T2DM of SNPs in these proteins were assessed in African American (AA), non-Hispanic White (NHW), and Hispanic American (HA) individuals. A total of 650 DNA samples were genotyped; control samples were obtained from Coriell's North American Human Variation Panel Repository (NAHVP) of apparently healthy individuals and T2DM cases were taken from the American Diabetes Association GENNID Study. The rs454550 SNP of FABP5 showed a significant association with T2DM in NHW (OR: 9.03, 95% CI: 1.13–71.73, p = 0.014). Our analysis also identified a new FABP5 SNP (nSNP) that showed a significant association with T2DM in NHW (OR: 0.44, 95% CI: 0.19–0.99, p = 0.045) and AA (OR: 0.17, 95% CI: 0.03–0.80, p = 0.016). The Ala54Thr FABP2 polymorphism was significantly associated with T2DM in HA individuals only (OR: 1.85, 95% CI: 1.05–3.27, p = 0.032). All other FABP SNPs did not show association with T2DM. These findings suggest a potential distinct role(s) of SNPs in FABP5 and FABP2 genes in T2DM in different populations.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21288588</pmid><doi>10.1016/j.diabres.2011.01.005</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Diabetes Mellitus, Type 2 - genetics Endocrinology & Metabolism Fatty acid binding protein (FABP) Fatty Acid-Binding Proteins - genetics Female Genetic Predisposition to Disease - genetics Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Single nucleotide polymorphism (SNP) Type 2 diabetes mellitus (T2DM) |
| title | Polymorphisms in fatty acid binding protein 5 show association with type 2 diabetes |
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