Actomyosin-generated tension controls the molecular kinetics of focal adhesions

Focal adhesions (FAs) have key roles in the interaction of cells with the extracellular matrix (ECM) and in adhesion-mediated signaling. These dynamic, multi-protein structures sense the ECM both chemically and physically, and respond to external and internal forces by changing their size and signal...

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Veröffentlicht in:	Journal of cell science 2011-05, Vol.124 (Pt 9), p.1425-1432
Hauptverfasser:	Wolfenson, Haguy, Bershadsky, Alexander, Henis, Yoav I, Geiger, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin - metabolism Cell Line, Tumor Cytoskeletal Proteins - metabolism Fluorescence Recovery After Photobleaching Focal Adhesions - drug effects Focal Adhesions - metabolism Glycoproteins - metabolism Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Oxazoles - pharmacology Paxillin - metabolism Vinculin - metabolism Zyxin
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