Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch
The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body wei...
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| Veröffentlicht in: | Canadian veterinary journal 2011-05, Vol.52 (5), p.501-505 |
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| container_title | Canadian veterinary journal |
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| creator | Claeys, Stéphanie Rustichelli, Frederico Noël, Stéphanie Hamaide, Annick |
| description | The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW). |
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Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. 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Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).</description><subject>Adrenergic alpha-Agonists - administration & dosage</subject><subject>Adrenergic alpha-Agonists - therapeutic use</subject><subject>Animals</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>Drug Administration Schedule - veterinary</subject><subject>Female</subject><subject>Life sciences</subject><subject>Médecine vétérinaire & santé animale</subject><subject>Phenylpropanolamine</subject><subject>Phenylpropanolamine - administration & dosage</subject><subject>Phenylpropanolamine - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Sciences du vivant</subject><subject>Scientific</subject><subject>Treatment Outcome</subject><subject>Urinary incontinence</subject><subject>Urinary Incontinence - drug therapy</subject><subject>Urinary Incontinence - veterinary</subject><subject>Urodynamics</subject><subject>Veterinary medicine & animal health</subject><issn>0008-5286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQzAFEy-MXkG-cKtlO4zgXJFTxkpC4wNmynU1j5NjBdir1H_hoTFsqOO1qdmZ2tHtSzDHGfFFRzmbFeYwfGNOGMHxWzCjFyxKzZl58raxxRkuLYCPtJJPxDvkOSRSNW1tArTR2i1of4Qcee3BbOwY_SuetHIwDZBxKPaAUQKYBXPrhTQFSH7JrHHvjdIKABtC9dCYOWaD9MEICp49qZZLuL4vTTtoIV4d6Ubw_3L-tnhYvr4_Pq7uXhS0xTwuCdVd1y1IBlqrmpKN62emKNrptmhpnWHGmWsYIIYwToASI1FRVvO3qTqvyorjd-46TGqDVOXTOKsZgBhm2wksj_k-c6cXab0SJa56vmA3o3sAaWIPwQRmxoTvhrp_sWkgtFAhKGReU8Jpn0c1ha_CfE8QkBhM1WCsd-CmKBhPGqgbXmXn9N98x2O_bym8fgJf-</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Claeys, Stéphanie</creator><creator>Rustichelli, Frederico</creator><creator>Noël, Stéphanie</creator><creator>Hamaide, Annick</creator><general>Canadian Veterinary Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope></search><sort><creationdate>201105</creationdate><title>Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch</title><author>Claeys, Stéphanie ; 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Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).</abstract><cop>Canada</cop><pub>Canadian Veterinary Medical Association</pub><pmid>22043069</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Canadian veterinary journal, 2011-05, Vol.52 (5), p.501-505 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - therapeutic use Animals Dog Diseases - drug therapy Dogs Drug Administration Schedule - veterinary Female Life sciences Médecine vétérinaire & santé animale Phenylpropanolamine Phenylpropanolamine - administration & dosage Phenylpropanolamine - therapeutic use Retrospective Studies Sciences du vivant Scientific Treatment Outcome Urinary incontinence Urinary Incontinence - drug therapy Urinary Incontinence - veterinary Urodynamics Veterinary medicine & animal health |
| title | Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch |
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