Functional Analysis of Two Cavities in Flavivirus NS5 Polymerase

Flavivirus NS5 protein encodes methyltransferase and RNA-dependent RNA polymerase (RdRp) activities. Structural analysis of flavivirus RdRp domains uncovered two conserved cavities (A and B). Both cavities are located in the thumb subdomains and represent potential targets for development of alloste...

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Veröffentlicht in:	The Journal of biological chemistry 2011-04, Vol.286 (16), p.14362-14372
Hauptverfasser:	Zou, Gang, Chen, Yen-Liang, Dong, Hongping, Lim, Chin Chin, Yap, Li Jian, Yau, Yin Hoe, Shochat, Susana Geifman, Lescar, Julien, Shi, Pei-Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cavities for Allosteric Inhibitor Chlorocebus aethiops Cricetinae Dengue Virus DNA-Directed RNA Polymerases - chemistry Drug Design Enzyme Mechanisms Enzymes - chemistry Flavivirus - enzymology Flaviviruses Lysine - chemistry Microbiology Molecular Sequence Data Mutagenesis, Site-Directed NS3/NS5 Interaction Protein Binding Protein Conformation Protein Interaction Mapping Protein-Protein Interactions RNA Polymerase RNA-Dependent RNA Polymerase - chemistry Sequence Homology, Amino Acid Site-directed Mutagenesis Tryptophan - chemistry Vero Cells Viral Nonstructural Proteins - chemistry Viral Replication Virus Replication
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