Ethanol Enhances Carbachol-induced Protease Activation and Accelerates Ca2+ Waves in Isolated Rat Pancreatic Acini

Alcohol abuse is a leading cause of pancreatitis, accounting for 30% of acute cases and 70–90% of chronic cases, yet the mechanisms leading to alcohol-associated pancreatic injury are unclear. An early and critical feature of pancreatitis is the aberrant signaling of Ca2+ within the pancreatic acina...

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Veröffentlicht in:	The Journal of biological chemistry 2011-04, Vol.286 (16), p.14090-14097
Hauptverfasser:	Orabi, Abrahim I., Shah, Ahsan U., Muili, Kamaldeen, Luo, Yuhuan, Mahmood, Syeda Maham, Ahmad, Asim, Reed, Anamika, Husain, Sohail Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cell Alcohol Alcoholism - physiopathology Animals Calcium - chemistry Calcium - metabolism Calcium Channels Calcium Imaging Calcium Intracellular Release Calcium Transport Carbachol - chemistry Carbachol - pharmacology Cell Biology Cholinergic Receptor Chymotrypsin - chemistry Dantrolene - pharmacology Disease Models, Animal Ethanol - pharmacology Muscle Relaxants, Central - pharmacology Pancreas Pancreas - metabolism Pancreas - pathology Pathologic Protease Activation Peptide Hydrolases - metabolism Rats Rats, Sprague-Dawley Ryanodine Receptor Ryanodine Receptor Calcium Release Channel - metabolism Signal Transduction Trypsin - chemistry
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