Study of Pulmonary Arterial Pressures and Histopathological Changes in Patients Having Congenital Heart Defects with Left-to-Right Shunt
Pulmonary arterial hypertension, a common complication in patients with congenital heart defects with left-to-right shunt who present late is one of the principal determinants of the clinical manifestations, the course and the feasibility of surgical repair. The objective is to study the pulmonary a...
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| Veröffentlicht in: | Indian journal of surgery 2011-04, Vol.73 (2), p.116-121 |
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| creator | Reddy, Srikrishna Modugula Thingnam, Shyam Kumar S. Joshi, Kusum |
| description | Pulmonary arterial hypertension, a common complication in patients with congenital heart defects with left-to-right shunt who present late is one of the principal determinants of the clinical manifestations, the course and the feasibility of surgical repair. The objective is to study the pulmonary arterial pressures and the pulmonary histopathological changes in patients having congenital heart defects with left-to-right shunt. A total of 20 consecutive patients having congenital heart defects with left-to- right shunt who underwent surgical correction were studied. Intra-operative mean pulmonary arterial pressures were measured before and after surgical correction. Lung biopsy was taken to study the histopathological changes of lung parenchyma and vasculature. All patients, irrespective of age at the time of surgical repair and the type and size of the cardiac defect had raised mean pulmonary arterial pressures that were decreased significantly immediately after surgical correction. Pulmonary parenchymal changes and vascular changes were noted in 18 and 9 patients respectively. The pulmonary vascular changes were significantly correlated with the mean pulmonary arterial pressures. The pulmonary parenchymal changes though were a consistent finding; not significantly correlated with the mean pulmonary arterial pressures. |
| doi_str_mv | 10.1007/s12262-010-0184-3 |
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The objective is to study the pulmonary arterial pressures and the pulmonary histopathological changes in patients having congenital heart defects with left-to-right shunt. A total of 20 consecutive patients having congenital heart defects with left-to- right shunt who underwent surgical correction were studied. Intra-operative mean pulmonary arterial pressures were measured before and after surgical correction. Lung biopsy was taken to study the histopathological changes of lung parenchyma and vasculature. All patients, irrespective of age at the time of surgical repair and the type and size of the cardiac defect had raised mean pulmonary arterial pressures that were decreased significantly immediately after surgical correction. Pulmonary parenchymal changes and vascular changes were noted in 18 and 9 patients respectively. The pulmonary vascular changes were significantly correlated with the mean pulmonary arterial pressures. 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The objective is to study the pulmonary arterial pressures and the pulmonary histopathological changes in patients having congenital heart defects with left-to-right shunt. A total of 20 consecutive patients having congenital heart defects with left-to- right shunt who underwent surgical correction were studied. Intra-operative mean pulmonary arterial pressures were measured before and after surgical correction. Lung biopsy was taken to study the histopathological changes of lung parenchyma and vasculature. All patients, irrespective of age at the time of surgical repair and the type and size of the cardiac defect had raised mean pulmonary arterial pressures that were decreased significantly immediately after surgical correction. Pulmonary parenchymal changes and vascular changes were noted in 18 and 9 patients respectively. The pulmonary vascular changes were significantly correlated with the mean pulmonary arterial pressures. The pulmonary parenchymal changes though were a consistent finding; not significantly correlated with the mean pulmonary arterial pressures.</description><subject>Blood pressure</subject><subject>Cardiac patients</subject><subject>Cardiac Surgery</subject><subject>Congenital diseases</subject><subject>Congenital heart defects</subject><subject>Congenital heart disease</subject><subject>Genetic disorders</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Hypertension</subject><subject>Lungs</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Neurosurgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Plastic Surgery</subject><subject>Pulmonary hypertension</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><issn>0972-2068</issn><issn>0973-9793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNUstuEzEUHSEQLYEPYIMsumA1xa8ZezZIUXgEKRIRhbXlOPaMq4ldbE9R_4DP5oaU0iJAyPJDPueeax-dqnpK8CnBWLzMhNKW1phgmJLX7F51jDvB6k507P6PM60pbuVR9Sjnc4wpbxl7WB1ROEjc4uPq21mZtlcoOrSexl0MOl2heSo2eT2idbI5T7AgHbZo6XOJF7oMcYy9N4AvBh16QH1Aa128DSWjpb70oUeLCEjwBVhLq1NBr62zBvCvvgxoZV2pS6w_-n4o6GyYQnlcPXB6zPbJ9T6rPr9982mxrFcf3r1fzFe1aRpeamup7Bqit6TRHWk76gwWmAvSEsYYb7Vp3IbqhnHiNOVusyGd4RtqO0eJFoLNqlcH3Ytps7NbA49OelQXye_g7ypqr-4iwQ-qj5eKYQFdOAi8uBZI8ctkc1E7n40dRx1snLLqWiYZpfCcWfX8N-Z5nFKA3ynZUNk0AjdAOjmQej1a5YOL0NXsJdWcd1xIIlv5TxaTFBwRmALr9A8sGFu78yYG6zzc35H9r4LbHcihwKSYc7LuxjiC1T6T6pBJBZlU-0yqvQ3Pbjt-U_EzhECgB0IGCGKTfvn0d9Xv4b7rGg</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>Reddy, Srikrishna Modugula</creator><creator>Thingnam, Shyam Kumar S.</creator><creator>Joshi, Kusum</creator><general>Springer India</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04T</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>Study of Pulmonary Arterial Pressures and Histopathological Changes in Patients Having Congenital Heart Defects with Left-to-Right Shunt</title><author>Reddy, Srikrishna Modugula ; Thingnam, Shyam Kumar S. ; Joshi, Kusum</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-ee28951ad15a91692fc0704716133346ac5fb2a5341fa24fbb19c4b2e9f21a773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Blood pressure</topic><topic>Cardiac patients</topic><topic>Cardiac Surgery</topic><topic>Congenital diseases</topic><topic>Congenital heart defects</topic><topic>Congenital heart disease</topic><topic>Genetic disorders</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Hypertension</topic><topic>Lungs</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Neurosurgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Plastic Surgery</topic><topic>Pulmonary hypertension</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, Srikrishna Modugula</creatorcontrib><creatorcontrib>Thingnam, Shyam Kumar S.</creatorcontrib><creatorcontrib>Joshi, Kusum</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Health & Medicine</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, Srikrishna Modugula</au><au>Thingnam, Shyam Kumar S.</au><au>Joshi, Kusum</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of Pulmonary Arterial Pressures and Histopathological Changes in Patients Having Congenital Heart Defects with Left-to-Right Shunt</atitle><jtitle>Indian journal of surgery</jtitle><stitle>Indian J Surg</stitle><addtitle>Indian J Surg</addtitle><date>2011-04-01</date><risdate>2011</risdate><volume>73</volume><issue>2</issue><spage>116</spage><epage>121</epage><pages>116-121</pages><issn>0972-2068</issn><eissn>0973-9793</eissn><abstract>Pulmonary arterial hypertension, a common complication in patients with congenital heart defects with left-to-right shunt who present late is one of the principal determinants of the clinical manifestations, the course and the feasibility of surgical repair. 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The pulmonary parenchymal changes though were a consistent finding; not significantly correlated with the mean pulmonary arterial pressures.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>22468060</pmid><doi>10.1007/s12262-010-0184-3</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Blood pressure Cardiac patients Cardiac Surgery Congenital diseases Congenital heart defects Congenital heart disease Genetic disorders Heart Heart surgery Hypertension Lungs Medical research Medicine Medicine & Public Health Medicine, Experimental Neurosurgery Original Original Article Pediatric Surgery Plastic Surgery Pulmonary hypertension Surgery Thoracic Surgery |
| title | Study of Pulmonary Arterial Pressures and Histopathological Changes in Patients Having Congenital Heart Defects with Left-to-Right Shunt |
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