The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

Two single-nucleotide polymorphisms (SNPs), rs1746048 and rs501120, from genome wide association studies of coronary artery disease (CAD) map to chromosome 10q11 ∼80 kb downstream of chemokine CXCL12. Therefore, we examined the relationship between these two SNPs and plasma CXCL12 levels. We tested...

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Veröffentlicht in:	European heart journal 2011-04, Vol.32 (8), p.963-971
Hauptverfasser:	MEHTA, Nehal N, MINGYAO LI, PATEL, Parth N, BRADFIELD, Jonathan P, JING HE, STYLIANOU, Loannis M, HAKONARSON, Hakon, RADER, Daniel J, REILLY, Muredach P, WILLIAM, Dilusha, KHERA, Amit V, DEROHANNESSIAN, Stephanie, LIMING QU, FERGUSON, Jane F, MCLAUGHLIN, Catherine, HARIS SHAIKH, Lalarukh, SHAH, Rhia
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Case-Control Studies Chemokine CXCL12 - blood Chromosomes, Human, Pair 10 - genetics Coronary Artery Disease - blood Coronary Artery Disease - genetics Coronary heart disease Enzyme-Linked Immunosorbent Assay Fasttrack Female Genome-Wide Association Study Heart Humans Linkage Disequilibrium Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Polymorphism, Single Nucleotide - genetics Risk Factors
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