Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis

Gastrointestinal toxicity is the primary limiting factor in abdominal and pelvic radiotherapy, but has no effective treatment currently. We recently showed a critical role of the BH3-only protein p53 upregulated modulator of apoptosis (PUMA) in acute radiation-induced GI damage and GI syndrome in mi...

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Veröffentlicht in:	Oncogene 2010-03, Vol.29 (11), p.1622-1632
Hauptverfasser:	Qiu, W, Leibowitz, B, Zhang, L, Yu, J
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Ageing, cell death AKT protein Animals Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Blotting, Western Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Epithelial cells Female Fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Gastroenterology Gastrointestinal diseases Genetics Growth factors HCT116 Cells Health aspects Human Genetics Humans In Situ Nick-End Labeling Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - pharmacology Insulin-like growth factors Intercellular Signaling Peptides and Proteins - pharmacology Internal Medicine Intestinal Mucosa - metabolism Intestine Intestines - cytology Kinases Male MDM2 protein Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Oncology original-article p53 Protein Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Protein kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism Radiation Radiation protection Radiation therapy Reverse Transcriptase Polymerase Chain Reaction Risk factors Signal Transduction - drug effects Signal Transduction - radiation effects Stem cell transplantation Stem cells Stem Cells - drug effects Stem Cells - metabolism Stem Cells - radiation effects Toxicity Tumor Suppressor Protein p53 - metabolism
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