Therapeutic cancer vaccines: are we there yet?

Enthusiasm for therapeutic cancer vaccines has been rejuvenated with the recent completion of several large, randomized phase III clinical trials that in some cases have reported an improvement in progression free or overall survival. However, an honest appraisal of their efficacy reveals modest cli...

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Veröffentlicht in:	Immunological reviews 2011-01, Vol.239 (1), p.27-44
Hauptverfasser:	Klebanoff, Christopher A., Acquavella, Nicolas, Yu, Zhiya, Restifo, Nicholas P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Adoptive Transfer Antigens, Differentiation, T-Lymphocyte - immunology Antigens, Neoplasm - immunology Cancer Vaccines - immunology Cancer Vaccines - therapeutic use cell intrinsic modulators of metabolism and memory formation CTLA-4 Humans Immunotherapy Indexing in process mTOR Neoplasms - immunology Neoplasms - therapy PD-1 Randomized Controlled Trials as Topic T-Lymphocyte Subsets - immunology Toll-like receptor agonist Toll-Like Receptors - agonists Treatment Outcome Wnt/β-catenin
Online-Zugang:	Volltext
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