Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice

Exposure to chronic and acute oxidative stress is correlated with many human diseases, including, but not limited to, cancer, heart disease, diabetes, and obesity. In addition to cellular lipids and proteins, cellular oxidative stress can result in damage to DNA bases, especially in mitochondrial DN...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2011-04, Vol.300 (4), p.E724-E734
Hauptverfasser:	Sampath, Harini, Batra, Ayesha K, Vartanian, Vladimir, Carmical, J Russ, Prusak, Deborah, King, Irena B, Lowell, Brian, Earley, Lauriel F, Wood, Thomas G, Marks, Daniel L, McCullough, Amanda K, R Stephen, Lloyd
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - drug effects Adiposity - genetics Animals Cells Deoxyribonucleic acid Diet Diet, Atherogenic Dietary Fats - adverse effects DNA DNA Glycosylases - genetics Female Genes Genetic Predisposition to Disease Genotype & phenotype Lipids Male Mice Mice, Inbred C57BL Mice, Knockout Obesity - epidemiology Obesity - etiology Obesity - genetics Obesity - metabolism Oxidative stress Oxidative Stress - genetics Oxidative Stress - physiology Penetrance Phenotype Prevalence Proteins Rodents Validation Studies as Topic
Online-Zugang:	Volltext
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