Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

Antisense oligodeoxynucleotides can selectively inhibit the expression of individual genes and thus have potential applications in anticancer and antiviral therapy. A critical prerequisite to their use as therapeutic agents is the understanding of their non-specific interactions with biological stru...

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Veröffentlicht in:	Nucleic acids research 1995-11, Vol.23 (21), p.4239-4245
Hauptverfasser:	Benimetskaya, Lyuba, Tonkinson, John L., Koziolkiewicz, Maria, Karwowski, Boleslaw, Guga, Piotr, Zeltser, Ross, Stec, Wojciech, Stein, C.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding, Competitive CD4 Antigens - metabolism Fibroblast Growth Factor 2 - metabolism Fibronectins - metabolism Isomerism Laminin - metabolism Molecular Probes Molecular Sequence Data Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Protein Binding Proteins - metabolism Structure-Activity Relationship Thionucleotides - chemistry Thionucleotides - metabolism
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