Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1
Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR) retrotransposon that has amplified to hundreds of thousands of copies in mammalian evolution. A small number of the individual copies of L1 are active retrotransposons which are presently replicating in most species, inc...
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| Veröffentlicht in: | RNA biology 2010-11, Vol.7 (6), p.706-711 |
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| creator | Martin, Sandra L. |
| description | Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR) retrotransposon that has amplified to hundreds of thousands of copies in mammalian evolution. A small number of the individual copies of L1 are active retrotransposons which are presently replicating in most species, including humans and mice. L1 retrotransposition begins with transcription of an active element and ends with a newly inserted cDNA copy, a process which requires the two element-encoded proteins to act in cis on the L1 RNA. The ORF1 protein (ORF1p) is a high-affinity, non-sequence-specific RNA binding protein with nucleic acid chaperone activity, whereas the ORF2 protein (ORF2p) supplies the enzymatic activities for cDNA synthesis. This article reviews the nucleic acid chaperone properties of ORF1p in the context of L1 retrotransposition. |
| doi_str_mv | 10.4161/rna.7.6.13766 |
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This article reviews the nucleic acid chaperone properties of ORF1p in the context of L1 retrotransposition.</description><identifier>ISSN: 1547-6286</identifier><identifier>EISSN: 1555-8584</identifier><identifier>DOI: 10.4161/rna.7.6.13766</identifier><identifier>PMID: 21045547</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Binding ; Biology ; Bioscience ; Calcium ; Cancer ; Cell ; Cycle ; Humans ; Landes ; Long Interspersed Nucleotide Elements - physiology ; Molecular Chaperones - metabolism ; Nucleic Acids - metabolism ; Open Reading Frames - physiology ; Organogenesis ; Proteins ; Review</subject><ispartof>RNA biology, 2010-11, Vol.7 (6), p.706-711</ispartof><rights>Copyright © 2010 Landes Bioscience 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-1ad72b5c7c3c9da2b061302d075ca41e8071ed65beaefce3174b7393993fef433</citedby><cites>FETCH-LOGICAL-c525t-1ad72b5c7c3c9da2b061302d075ca41e8071ed65beaefce3174b7393993fef433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073329/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073329/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21045547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Sandra L.</creatorcontrib><title>Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1</title><title>RNA biology</title><addtitle>RNA Biol</addtitle><description>Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR) retrotransposon that has amplified to hundreds of thousands of copies in mammalian evolution. 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This article reviews the nucleic acid chaperone properties of ORF1p in the context of L1 retrotransposition.</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cycle</subject><subject>Humans</subject><subject>Landes</subject><subject>Long Interspersed Nucleotide Elements - physiology</subject><subject>Molecular Chaperones - metabolism</subject><subject>Nucleic Acids - metabolism</subject><subject>Open Reading Frames - physiology</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Review</subject><issn>1547-6286</issn><issn>1555-8584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2PFCEQxYnRuB969Gq4ebFHaBrovphsNrvrJuNsMq5nQkOxg-mGFno089_LOOuoiYknKtSPV496CL2iZNFQQd-loBdyIRaUSSGeoFPKOa9a3jZP93UjK1G34gSd5fyFECbajj9HJzUlDS_NU_RptTUDeIO18RabjZ4gxQB4SrFUs4eMo8N362s6YZfiiOcN4BBDtbxf4wRzinPSIU8xx_AWL29XVxV9gZ45PWR4-Xieo8_XV_eXH6rl3c3t5cWyMrzmc0W1lXXPjTTMdFbXPRGUkdoSyY1uKLREUrCC96DBGWBUNr1kHes65sA1jJ2j9wfdaduPYA2E4mVQU_KjTjsVtVd_d4LfqIf4TTEiGau7IvDmUSDFr1vIsxp9NjAMOkDcZlXWKIuLpi5kdSBNijkncMcplKh9DqrkoKQS6mcOhX_9p7Uj_WvxBWgPQJllIfc-ZuMhGDiiRbDcDvFhp3QJoqR01Cb_efpx_yCsVxd7Q5N1v6f54GIa9feYBqtmvRticiU_47Ni__7JD5EavyM</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Martin, Sandra L.</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101101</creationdate><title>Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1</title><author>Martin, Sandra L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-1ad72b5c7c3c9da2b061302d075ca41e8071ed65beaefce3174b7393993fef433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cycle</topic><topic>Humans</topic><topic>Landes</topic><topic>Long Interspersed Nucleotide Elements - physiology</topic><topic>Molecular Chaperones - metabolism</topic><topic>Nucleic Acids - metabolism</topic><topic>Open Reading Frames - physiology</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Sandra L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RNA biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Sandra L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1</atitle><jtitle>RNA biology</jtitle><addtitle>RNA Biol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>7</volume><issue>6</issue><spage>706</spage><epage>711</epage><pages>706-711</pages><issn>1547-6286</issn><eissn>1555-8584</eissn><abstract>Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR) retrotransposon that has amplified to hundreds of thousands of copies in mammalian evolution. 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| ispartof | RNA biology, 2010-11, Vol.7 (6), p.706-711 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Binding Biology Bioscience Calcium Cancer Cell Cycle Humans Landes Long Interspersed Nucleotide Elements - physiology Molecular Chaperones - metabolism Nucleic Acids - metabolism Open Reading Frames - physiology Organogenesis Proteins Review |
| title | Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1 |
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