Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study
Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study.Design Combination of prospective cohort study with representative population based data on alcohol exposure.Settin...
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| Veröffentlicht in: | BMJ 2011-04, Vol.342 (apr07 1), p.d1584-d1584 |
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| creator | Schütze, Madlen Boeing, Heiner Pischon, Tobias Rehm, Jürgen Kehoe, Tara Gmel, Gerrit Olsen, Anja Tjønneland, Anne M Dahm, Christina C Overvad, Kim Clavel-Chapelon, Françoise Boutron-Ruault, Marie-Christine Trichopoulou, Antonia Benetou, Vasiliki Zylis, Dimosthenis Kaaks, Rudolf Rohrmann, Sabine Palli, Domenico Berrino, Franco Tumino, Rosario Vineis, Paolo Rodríguez, Laudina Agudo, Antonio Sánchez, María-José Dorronsoro, Miren Chirlaque, Maria-Dolores Barricarte, Aurelio Peeters, Petra H van Gils, Carla H Khaw, Kay-Tee Wareham, Nick Allen, Naomi E Key, Timothy J Boffetta, Paolo Slimani, Nadia Jenab, Mazda Romaguera, Dora Wark, Petra A Riboli, Elio Bergmann, Manuela M |
| description | Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study.Design Combination of prospective cohort study with representative population based data on alcohol exposure.Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Participants 109 118 men and 254 870 women, mainly aged 37-70.Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer.Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women.Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer. |
| doi_str_mv | 10.1136/bmj.d1584 |
| format | Article |
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Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer.Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women.Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.</description><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>EISSN: 1756-1833</identifier><identifier>DOI: 10.1136/bmj.d1584</identifier><identifier>PMID: 21474525</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Adult ; Aged ; Alcohol Drinking - mortality ; Alcohol use ; Alcoholic beverages ; Breast Cancer ; Cohort analysis ; Colon Cancer ; Colorectal carcinoma ; Cost of Illness ; Epidemiologic Studies ; Europe - epidemiology ; Female ; Health Education ; Health Promotion ; Health risk assessment ; Humans ; Incidence ; Liver ; Male ; Middle Aged ; Mortality ; Neoplasms - etiology ; Neoplasms - mortality ; Population studies ; Prospective Studies ; Sex Distribution ; Womens health</subject><ispartof>BMJ, 2011-04, Vol.342 (apr07 1), p.d1584-d1584</ispartof><rights>Schütze et al 2011</rights><rights>Copyright: 2011 © Schütze et al 2011</rights><rights>Schütze et al 2011 2011 Schütze et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b567t-63f9b5547b0bdf645c6265ff0ddc2febf715a4b7aae80571ec8737549dd882473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bmj.com/content/342/bmj.d1584.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://bmj.com/content/342/bmj.d1584.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,777,781,882,3183,23552,27905,27906,77349,77380</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21474525$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schütze, Madlen</creatorcontrib><creatorcontrib>Boeing, Heiner</creatorcontrib><creatorcontrib>Pischon, Tobias</creatorcontrib><creatorcontrib>Rehm, Jürgen</creatorcontrib><creatorcontrib>Kehoe, Tara</creatorcontrib><creatorcontrib>Gmel, Gerrit</creatorcontrib><creatorcontrib>Olsen, Anja</creatorcontrib><creatorcontrib>Tjønneland, Anne M</creatorcontrib><creatorcontrib>Dahm, Christina C</creatorcontrib><creatorcontrib>Overvad, Kim</creatorcontrib><creatorcontrib>Clavel-Chapelon, Françoise</creatorcontrib><creatorcontrib>Boutron-Ruault, Marie-Christine</creatorcontrib><creatorcontrib>Trichopoulou, Antonia</creatorcontrib><creatorcontrib>Benetou, Vasiliki</creatorcontrib><creatorcontrib>Zylis, Dimosthenis</creatorcontrib><creatorcontrib>Kaaks, Rudolf</creatorcontrib><creatorcontrib>Rohrmann, Sabine</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Berrino, Franco</creatorcontrib><creatorcontrib>Tumino, Rosario</creatorcontrib><creatorcontrib>Vineis, Paolo</creatorcontrib><creatorcontrib>Rodríguez, Laudina</creatorcontrib><creatorcontrib>Agudo, Antonio</creatorcontrib><creatorcontrib>Sánchez, María-José</creatorcontrib><creatorcontrib>Dorronsoro, Miren</creatorcontrib><creatorcontrib>Chirlaque, Maria-Dolores</creatorcontrib><creatorcontrib>Barricarte, Aurelio</creatorcontrib><creatorcontrib>Peeters, Petra H</creatorcontrib><creatorcontrib>van Gils, Carla H</creatorcontrib><creatorcontrib>Khaw, Kay-Tee</creatorcontrib><creatorcontrib>Wareham, Nick</creatorcontrib><creatorcontrib>Allen, Naomi E</creatorcontrib><creatorcontrib>Key, Timothy J</creatorcontrib><creatorcontrib>Boffetta, Paolo</creatorcontrib><creatorcontrib>Slimani, Nadia</creatorcontrib><creatorcontrib>Jenab, Mazda</creatorcontrib><creatorcontrib>Romaguera, Dora</creatorcontrib><creatorcontrib>Wark, Petra A</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Bergmann, Manuela M</creatorcontrib><title>Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study</title><title>BMJ</title><addtitle>BMJ</addtitle><description>Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study.Design Combination of prospective cohort study with representative population based data on alcohol exposure.Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Participants 109 118 men and 254 870 women, mainly aged 37-70.Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer.Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women.Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - mortality</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Breast Cancer</subject><subject>Cohort analysis</subject><subject>Colon Cancer</subject><subject>Colorectal carcinoma</subject><subject>Cost of Illness</subject><subject>Epidemiologic Studies</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Health Education</subject><subject>Health Promotion</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - mortality</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Sex Distribution</subject><subject>Womens 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Madlen</creator><creator>Boeing, Heiner</creator><creator>Pischon, Tobias</creator><creator>Rehm, Jürgen</creator><creator>Kehoe, Tara</creator><creator>Gmel, Gerrit</creator><creator>Olsen, Anja</creator><creator>Tjønneland, Anne M</creator><creator>Dahm, Christina C</creator><creator>Overvad, Kim</creator><creator>Clavel-Chapelon, Françoise</creator><creator>Boutron-Ruault, Marie-Christine</creator><creator>Trichopoulou, Antonia</creator><creator>Benetou, Vasiliki</creator><creator>Zylis, Dimosthenis</creator><creator>Kaaks, Rudolf</creator><creator>Rohrmann, Sabine</creator><creator>Palli, Domenico</creator><creator>Berrino, Franco</creator><creator>Tumino, Rosario</creator><creator>Vineis, Paolo</creator><creator>Rodríguez, Laudina</creator><creator>Agudo, Antonio</creator><creator>Sánchez, María-José</creator><creator>Dorronsoro, Miren</creator><creator>Chirlaque, Maria-Dolores</creator><creator>Barricarte, Aurelio</creator><creator>Peeters, Petra H</creator><creator>van Gils, Carla H</creator><creator>Khaw, Kay-Tee</creator><creator>Wareham, Nick</creator><creator>Allen, Naomi E</creator><creator>Key, Timothy J</creator><creator>Boffetta, Paolo</creator><creator>Slimani, Nadia</creator><creator>Jenab, Mazda</creator><creator>Romaguera, Dora</creator><creator>Wark, Petra A</creator><creator>Riboli, Elio</creator><creator>Bergmann, Manuela M</creator><general>British Medical Journal Publishing Group</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group 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attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study</title><author>Schütze, Madlen ; Boeing, Heiner ; Pischon, Tobias ; Rehm, Jürgen ; Kehoe, Tara ; Gmel, Gerrit ; Olsen, Anja ; Tjønneland, Anne M ; Dahm, Christina C ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Trichopoulou, Antonia ; Benetou, Vasiliki ; Zylis, Dimosthenis ; Kaaks, Rudolf ; Rohrmann, Sabine ; Palli, Domenico ; Berrino, Franco ; Tumino, Rosario ; Vineis, Paolo ; Rodríguez, Laudina ; Agudo, Antonio ; Sánchez, María-José ; Dorronsoro, Miren ; Chirlaque, Maria-Dolores ; Barricarte, Aurelio ; Peeters, Petra H ; van Gils, Carla H ; Khaw, Kay-Tee ; Wareham, Nick ; Allen, Naomi E ; Key, Timothy J ; Boffetta, Paolo ; Slimani, Nadia ; Jenab, Mazda ; Romaguera, Dora ; Wark, Petra A ; Riboli, Elio ; Bergmann, Manuela 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Dora</creatorcontrib><creatorcontrib>Wark, Petra A</creatorcontrib><creatorcontrib>Riboli, Elio</creatorcontrib><creatorcontrib>Bergmann, Manuela M</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium 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Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schütze, Madlen</au><au>Boeing, Heiner</au><au>Pischon, Tobias</au><au>Rehm, Jürgen</au><au>Kehoe, Tara</au><au>Gmel, Gerrit</au><au>Olsen, Anja</au><au>Tjønneland, Anne M</au><au>Dahm, Christina C</au><au>Overvad, Kim</au><au>Clavel-Chapelon, Françoise</au><au>Boutron-Ruault, Marie-Christine</au><au>Trichopoulou, Antonia</au><au>Benetou, Vasiliki</au><au>Zylis, Dimosthenis</au><au>Kaaks, Rudolf</au><au>Rohrmann, Sabine</au><au>Palli, Domenico</au><au>Berrino, Franco</au><au>Tumino, Rosario</au><au>Vineis, Paolo</au><au>Rodríguez, Laudina</au><au>Agudo, Antonio</au><au>Sánchez, María-José</au><au>Dorronsoro, Miren</au><au>Chirlaque, Maria-Dolores</au><au>Barricarte, Aurelio</au><au>Peeters, Petra H</au><au>van Gils, Carla H</au><au>Khaw, Kay-Tee</au><au>Wareham, Nick</au><au>Allen, Naomi E</au><au>Key, Timothy J</au><au>Boffetta, Paolo</au><au>Slimani, Nadia</au><au>Jenab, Mazda</au><au>Romaguera, Dora</au><au>Wark, Petra A</au><au>Riboli, Elio</au><au>Bergmann, Manuela M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study</atitle><jtitle>BMJ</jtitle><addtitle>BMJ</addtitle><date>2011-04-07</date><risdate>2011</risdate><volume>342</volume><issue>apr07 1</issue><spage>d1584</spage><epage>d1584</epage><pages>d1584-d1584</pages><issn>0959-8138</issn><eissn>1468-5833</eissn><eissn>1756-1833</eissn><abstract>Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study.Design Combination of prospective cohort study with representative population based data on alcohol exposure.Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Participants 109 118 men and 254 870 women, mainly aged 37-70.Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer.Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women.Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>21474525</pmid><doi>10.1136/bmj.d1584</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0959-8138 |
| ispartof | BMJ, 2011-04, Vol.342 (apr07 1), p.d1584-d1584 |
| issn | 0959-8138 1468-5833 1756-1833 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3072472 |
| source | MEDLINE; BMJ Journals - NESLi2; Jstor Complete Legacy |
| subjects | Adult Aged Alcohol Drinking - mortality Alcohol use Alcoholic beverages Breast Cancer Cohort analysis Colon Cancer Colorectal carcinoma Cost of Illness Epidemiologic Studies Europe - epidemiology Female Health Education Health Promotion Health risk assessment Humans Incidence Liver Male Middle Aged Mortality Neoplasms - etiology Neoplasms - mortality Population studies Prospective Studies Sex Distribution Womens health |
| title | Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study |
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