The COPI vesicle complex binds and moves with survival motor neuron within axons

Spinal muscular atrophy (SMA), an inherited disease of motor neuron dysfunction, results from insufficient levels of the survival motor neuron (SMN) protein. Movement of the SMN protein as granules within cultured axons suggests that the pathogenesis of SMA may involve defects in neuronal transport,...

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Veröffentlicht in:	Human molecular genetics 2011-05, Vol.20 (9), p.1701-1711
Hauptverfasser:	JAYAKUMAR PETER, Cyril, EVANS, Matthew, ANDROPHY, Elliot J, THAYANITHY, Venugopal, TANIGUCHI-ISHIGAKI, Naoko, BACH, Ingolf, KOLPAK, Adrianne, BASSELL, Gary J, ROSSOLL, Wilfried, LORSON, Christian L, BAO, Zheng-Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Axonal transport Axons Axons - metabolism Biological and medical sciences Cell Line Cell Survival Coat protein Coat Protein Complex I - genetics Coat Protein Complex I - metabolism Disease Models, Animal Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Golgi apparatus Granules Growth cones Hereditary diseases Humans Mice Molecular and cellular biology Motor neurons Motor Neurons - cytology Motor Neurons - metabolism mRNA Muscular Atrophy, Spinal - genetics Muscular Atrophy, Spinal - metabolism Protein Binding Protein Transport Pseudopodia SMN protein spinal muscular atrophy Survival of Motor Neuron 1 Protein - genetics Survival of Motor Neuron 1 Protein - metabolism Transport Vesicles - genetics Transport Vesicles - metabolism Vesicles
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