Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents

Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC values in the range of 0.5−6 μg/mL (2−15 μM) for their antibacterial activity against Mtb H37Rv strain. Moreover, five of the lead compounds also...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-01, Vol.54 (1), p.374-381
Hauptverfasser:	Kumar, Kunal, Awasthi, Divya, Lee, Seung-Yub, Zanardi, Ilaria, Ruzsicska, Bela, Knudson, Susan, Tonge, Peter J, Slayden, Richard A, Ojima, Iwao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Bacterial Proteins - metabolism Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Cercopithecus aethiops Cytoskeletal Proteins - metabolism GTP Phosphohydrolases - metabolism Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - metabolism Structure-Activity Relationship Vero Cells
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