Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures
Summary Purpose: Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE). Methods: We used radial atrophy mapping (RAM), a three‐dimensional (3D) surface modeling tool, to measure hi...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2011-04, Vol.52 (4), p.689-697 |
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| creator | Finegersh, Andrey Avedissian, Christina Shamim, Sadat Dustin, Irene Thompson, Paul M. Theodore, William H. |
| description | Summary
Purpose: Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).
Methods: We used radial atrophy mapping (RAM), a three‐dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.
Key Findings: Subjects with a history of febrile seizures (n = 15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI‐II) score ≥14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI‐II |
| doi_str_mv | 10.1111/j.1528-1167.2010.02928.x |
| format | Article |
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Purpose: Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).
Methods: We used radial atrophy mapping (RAM), a three‐dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.
Key Findings: Subjects with a history of febrile seizures (n = 15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI‐II) score ≥14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI‐II <14 (n = 29).
Significance: Contralateral hippocampal atrophy in TLE may be related to febrile seizures or depression.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2010.02928.x</identifier><identifier>PMID: 21269286</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Atrophy ; Biological and medical sciences ; Brain mapping ; Convulsions & seizures ; Depression ; Depressive Disorder - complications ; Depressive Disorder - pathology ; Epilepsy ; Epilepsy, Temporal Lobe - complications ; Epilepsy, Temporal Lobe - pathology ; Febrile seizures ; Female ; Fever ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Hippocampus ; Hippocampus - pathology ; Humans ; Inventories ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neuroimaging ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Radial mapping ; Seizures ; Seizures, Febrile - complications ; Seizures, Febrile - pathology ; Temporal lobe ; Temporal lobe epilepsy ; Young Adult</subject><ispartof>Epilepsia (Copenhagen), 2011-04, Vol.52 (4), p.689-697</ispartof><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.</rights><rights>2010 International League Against Epilepsy 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6298-38f1ae44e3360a8a7ec2e8c6abd0123c2218682cfcd88c2149a73edef4d8fb4e3</citedby><cites>FETCH-LOGICAL-c6298-38f1ae44e3360a8a7ec2e8c6abd0123c2218682cfcd88c2149a73edef4d8fb4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2010.02928.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2010.02928.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24104007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21269286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finegersh, Andrey</creatorcontrib><creatorcontrib>Avedissian, Christina</creatorcontrib><creatorcontrib>Shamim, Sadat</creatorcontrib><creatorcontrib>Dustin, Irene</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Theodore, William H.</creatorcontrib><title>Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose: Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).
Methods: We used radial atrophy mapping (RAM), a three‐dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.
Key Findings: Subjects with a history of febrile seizures (n = 15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI‐II) score ≥14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI‐II <14 (n = 29).
Significance: Contralateral hippocampal atrophy in TLE may be related to febrile seizures or depression.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Brain mapping</subject><subject>Convulsions & seizures</subject><subject>Depression</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - pathology</subject><subject>Epilepsy</subject><subject>Epilepsy, Temporal Lobe - complications</subject><subject>Epilepsy, Temporal Lobe - pathology</subject><subject>Febrile seizures</subject><subject>Female</subject><subject>Fever</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Hippocampus</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Inventories</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Radial mapping</subject><subject>Seizures</subject><subject>Seizures, Febrile - complications</subject><subject>Seizures, Febrile - pathology</subject><subject>Temporal lobe</subject><subject>Temporal lobe epilepsy</subject><subject>Young Adult</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2P1CAUhonRuOPqXzAkxnjVkY9OoSaa6GbUTTbRC70mlB4cxrYgtOvWXy91xvHjarnhhPO8bw68IIQpWdO8nu_XdMNkQWkl1ozkU8JqJtc3d9Dq1LiLVoRQXtQbSc7Qg5T2hBBRCX4fnTHKqiyoVujrG9fpEaLu8M6F4I3uQ671GH3YzdgNeIQ--KXf-QYwBNdBSPMLvLUWzIi9xS2ECCm5a8Bp7sPo-4T10GILTcw0TuB-TJl4iO5Z3SV4dNzP0ee3208X74urD-8uL15fFaZitSy4tFRDWQLnFdFSCzAMpKl00xLKuGGMykoyY00rpWG0rLXg0IItW2mbLDtHrw6-YWp6aA0MY55fheh6HWfltVP_dga3U1_8teJE0JJtssGzo0H03yZIo-pdMtB1egA_JSUrIbisxW1IwuuqZDyTT_4j936KQ34HRTdUMC5kXWZKHigTfUoR7GlqStQSvdqrJWG1JKyW6NWv6NVNlj7--9Yn4e-sM_D0COhkdGejHoxLf7iSkjL_kMy9PHDfc3jzrQdQ24-XS8V_Atv7zE0</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Finegersh, Andrey</creator><creator>Avedissian, Christina</creator><creator>Shamim, Sadat</creator><creator>Dustin, Irene</creator><creator>Thompson, Paul M.</creator><creator>Theodore, William H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201104</creationdate><title>Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures</title><author>Finegersh, Andrey ; Avedissian, Christina ; Shamim, Sadat ; Dustin, Irene ; Thompson, Paul M. ; Theodore, William H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6298-38f1ae44e3360a8a7ec2e8c6abd0123c2218682cfcd88c2149a73edef4d8fb4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Brain mapping</topic><topic>Convulsions & seizures</topic><topic>Depression</topic><topic>Depressive Disorder - complications</topic><topic>Depressive Disorder - pathology</topic><topic>Epilepsy</topic><topic>Epilepsy, Temporal Lobe - complications</topic><topic>Epilepsy, Temporal Lobe - pathology</topic><topic>Febrile seizures</topic><topic>Female</topic><topic>Fever</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Hippocampus</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Inventories</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Radial mapping</topic><topic>Seizures</topic><topic>Seizures, Febrile - complications</topic><topic>Seizures, Febrile - pathology</topic><topic>Temporal lobe</topic><topic>Temporal lobe epilepsy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finegersh, Andrey</creatorcontrib><creatorcontrib>Avedissian, Christina</creatorcontrib><creatorcontrib>Shamim, Sadat</creatorcontrib><creatorcontrib>Dustin, Irene</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Theodore, William H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finegersh, Andrey</au><au>Avedissian, Christina</au><au>Shamim, Sadat</au><au>Dustin, Irene</au><au>Thompson, Paul M.</au><au>Theodore, William H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2011-04</date><risdate>2011</risdate><volume>52</volume><issue>4</issue><spage>689</spage><epage>697</epage><pages>689-697</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose: Neuroimaging studies suggest a history of febrile seizures, and depression, are associated with hippocampal volume reductions in patients with temporal lobe epilepsy (TLE).
Methods: We used radial atrophy mapping (RAM), a three‐dimensional (3D) surface modeling tool, to measure hippocampal atrophy in 40 patients with unilateral TLE, with or without a history of febrile seizures and symptoms of depression. Multiple linear regression was used to single out the effects of covariates on local atrophy.
Key Findings: Subjects with a history of febrile seizures (n = 15) had atrophy in regions corresponding to the CA1 and CA3 subfields of the hippocampus contralateral to seizure focus (CHC) compared to those without a history of febrile seizures (n = 25). Subjects with Beck Depression Inventory II (BDI‐II) score ≥14 (n = 11) had atrophy in the superoanterior portion of the CHC compared to subjects with BDI‐II <14 (n = 29).
Significance: Contralateral hippocampal atrophy in TLE may be related to febrile seizures or depression.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21269286</pmid><doi>10.1111/j.1528-1167.2010.02928.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Atrophy Biological and medical sciences Brain mapping Convulsions & seizures Depression Depressive Disorder - complications Depressive Disorder - pathology Epilepsy Epilepsy, Temporal Lobe - complications Epilepsy, Temporal Lobe - pathology Febrile seizures Female Fever Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - pathology Humans Inventories Male Medical sciences Mental depression Middle Aged Nervous system (semeiology, syndromes) Neuroimaging Neurology Neuropharmacology Pharmacology. Drug treatments Radial mapping Seizures Seizures, Febrile - complications Seizures, Febrile - pathology Temporal lobe Temporal lobe epilepsy Young Adult |
| title | Bilateral hippocampal atrophy in temporal lobe epilepsy: Effect of depressive symptoms and febrile seizures |
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