Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination
Functional characteristics of tuberculosis (TB)—specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, in...
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| Veröffentlicht in: | The Journal of infectious diseases 2011-02, Vol.203 (3), p.378-382 |
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| container_title | The Journal of infectious diseases |
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| creator | Streitz, Mathias Fuhrmann, Stephan Powell, Fiona Quassem, Ali Nomura, Laurel Maecker, Holden Martus, Peter Volk, Hans-Dieter Kern, Florian |
| description | Functional characteristics of tuberculosis (TB)—specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon γ [IFN-γ], tumor necrosis factor α [TNF-α], and interleukin 2 [IL-2\ production). Interestingly, CD154 upregulation accounted for ∼80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-γ accounted for only ∼50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-γ production alone. |
| doi_str_mv | 10.1093/infdis/jiq065 |
| format | Article |
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Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon γ [IFN-γ], tumor necrosis factor α [TNF-α], and interleukin 2 [IL-2\ production). Interestingly, CD154 upregulation accounted for ∼80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-γ accounted for only ∼50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-γ production alone.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiq065</identifier><identifier>PMID: 21186260</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; BACTERIA ; Bacterial diseases ; Bacterial diseases of the respiratory system ; BCG Vaccine - immunology ; Biological and medical sciences ; Blood ; CD40 Ligand - genetics ; CD40 Ligand - metabolism ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Major and Brief Reports ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Mycobacterium ; Mycobacterium tuberculosis ; Pulmonary tuberculosis ; T lymphocytes ; T-Lymphocytes - immunology ; T-Lymphocytes - physiology ; Tuberculin ; Tuberculin - immunology ; Tuberculosis ; Tuberculosis vaccine ; Tuberculosis, Pulmonary - blood ; Tuberculosis, Pulmonary - immunology ; Tuberculosis, Pulmonary - pathology ; Tuberculosis, Pulmonary - prevention & control ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Up regulation ; Vaccination</subject><ispartof>The Journal of infectious diseases, 2011-02, Vol.203 (3), p.378-382</ispartof><rights>Copyright © 2011 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2010. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-a9e5eb57ad56a20914ce4353420b75128f4ede925fdd8e7d143bd996bf54b7d3</citedby><cites>FETCH-LOGICAL-c504t-a9e5eb57ad56a20914ce4353420b75128f4ede925fdd8e7d143bd996bf54b7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25764855$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25764855$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,1578,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23816875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21186260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Streitz, Mathias</creatorcontrib><creatorcontrib>Fuhrmann, Stephan</creatorcontrib><creatorcontrib>Powell, Fiona</creatorcontrib><creatorcontrib>Quassem, Ali</creatorcontrib><creatorcontrib>Nomura, Laurel</creatorcontrib><creatorcontrib>Maecker, Holden</creatorcontrib><creatorcontrib>Martus, Peter</creatorcontrib><creatorcontrib>Volk, Hans-Dieter</creatorcontrib><creatorcontrib>Kern, Florian</creatorcontrib><title>Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Functional characteristics of tuberculosis (TB)—specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon γ [IFN-γ], tumor necrosis factor α [TNF-α], and interleukin 2 [IL-2\ production). Interestingly, CD154 upregulation accounted for ∼80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-γ accounted for only ∼50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-γ production alone.</description><subject>Adult</subject><subject>BACTERIA</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>BCG Vaccine - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>CD40 Ligand - genetics</subject><subject>CD40 Ligand - metabolism</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis</subject><subject>Pulmonary tuberculosis</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - physiology</subject><subject>Tuberculin</subject><subject>Tuberculin - immunology</subject><subject>Tuberculosis</subject><subject>Tuberculosis vaccine</subject><subject>Tuberculosis, Pulmonary - blood</subject><subject>Tuberculosis, Pulmonary - immunology</subject><subject>Tuberculosis, Pulmonary - pathology</subject><subject>Tuberculosis, Pulmonary - prevention & control</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Up regulation</subject><subject>Vaccination</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctv1DAQxiMEog84cgT5gsol1O8kF6RtBKXSSlQ04mo5tgNeJXZqOxX89xhluy0XOM1I85tvHl9RvELwPYINObdu0Dae7-wt5OxJcQwhxiWqm-bpo_yoOIlxByGkhFfPiyOMUM0xh8fFz27pTVDLaF15MxtlB6tAB1ozjhFsggFfjV6U0cA6sFHJ3hlwvYyTdzL8Ave9PtoIWj_NMmQyebDtLq6AD-AmybREcO1jAhftJfgmlbJOJuvdi-LZIMdoXu7jadF9-ti1n8vtl8urdrMtFYM0lbIxzPSskppxiWGDqDKUMEIx7CuGcD1Qo02D2aB1bSqNKOl10_B-YLSvNDktPqyy89JPRivjUpCjmIOd8gXCSyv-rjj7Q3z3d4LACiHEssDZXiD428XEJCYbVX6PdMYvUdQY5wcjDDP57p8k4qShFWWEZLRcURV8jMEMh4UQFH9sFautYrU1828eX3Gg733MwNs9IKOS4xCkU7n9wJEa8bpiDzv6Zf7vzNcruovJhwcpVnFaM0Z-A8E8xb0</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Streitz, Mathias</creator><creator>Fuhrmann, Stephan</creator><creator>Powell, Fiona</creator><creator>Quassem, Ali</creator><creator>Nomura, Laurel</creator><creator>Maecker, Holden</creator><creator>Martus, Peter</creator><creator>Volk, Hans-Dieter</creator><creator>Kern, Florian</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110201</creationdate><title>Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination</title><author>Streitz, Mathias ; Fuhrmann, Stephan ; Powell, Fiona ; Quassem, Ali ; Nomura, Laurel ; Maecker, Holden ; Martus, Peter ; Volk, Hans-Dieter ; Kern, Florian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-a9e5eb57ad56a20914ce4353420b75128f4ede925fdd8e7d143bd996bf54b7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>BACTERIA</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>BCG Vaccine - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>CD40 Ligand - genetics</topic><topic>CD40 Ligand - metabolism</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Major and Brief Reports</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis</topic><topic>Pulmonary tuberculosis</topic><topic>T lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - physiology</topic><topic>Tuberculin</topic><topic>Tuberculin - immunology</topic><topic>Tuberculosis</topic><topic>Tuberculosis vaccine</topic><topic>Tuberculosis, Pulmonary - blood</topic><topic>Tuberculosis, Pulmonary - immunology</topic><topic>Tuberculosis, Pulmonary - pathology</topic><topic>Tuberculosis, Pulmonary - prevention & control</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Up regulation</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Streitz, Mathias</creatorcontrib><creatorcontrib>Fuhrmann, Stephan</creatorcontrib><creatorcontrib>Powell, Fiona</creatorcontrib><creatorcontrib>Quassem, Ali</creatorcontrib><creatorcontrib>Nomura, Laurel</creatorcontrib><creatorcontrib>Maecker, Holden</creatorcontrib><creatorcontrib>Martus, Peter</creatorcontrib><creatorcontrib>Volk, Hans-Dieter</creatorcontrib><creatorcontrib>Kern, Florian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Streitz, Mathias</au><au>Fuhrmann, Stephan</au><au>Powell, Fiona</au><au>Quassem, Ali</au><au>Nomura, Laurel</au><au>Maecker, Holden</au><au>Martus, Peter</au><au>Volk, Hans-Dieter</au><au>Kern, Florian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>203</volume><issue>3</issue><spage>378</spage><epage>382</epage><pages>378-382</pages><issn>0022-1899</issn><issn>1537-6613</issn><eissn>0022-1899</eissn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Functional characteristics of tuberculosis (TB)—specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon γ [IFN-γ], tumor necrosis factor α [TNF-α], and interleukin 2 [IL-2\ production). Interestingly, CD154 upregulation accounted for ∼80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-γ accounted for only ∼50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-γ production alone.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21186260</pmid><doi>10.1093/infdis/jiq065</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2011-02, Vol.203 (3), p.378-382 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult BACTERIA Bacterial diseases Bacterial diseases of the respiratory system BCG Vaccine - immunology Biological and medical sciences Blood CD40 Ligand - genetics CD40 Ligand - metabolism Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Human bacterial diseases Humans Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Mycobacterium Mycobacterium tuberculosis Pulmonary tuberculosis T lymphocytes T-Lymphocytes - immunology T-Lymphocytes - physiology Tuberculin Tuberculin - immunology Tuberculosis Tuberculosis vaccine Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - pathology Tuberculosis, Pulmonary - prevention & control Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up regulation Vaccination |
| title | Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination |
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