Penetration and Activation of Brain Endothelium by Salmonella enterica Serovar Typhimurium
Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the bl...
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| Veröffentlicht in: | The Journal of infectious diseases 2011-02, Vol.203 (3), p.401-405 |
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| container_title | The Journal of infectious diseases |
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| creator | van Sorge, Nina M. Zialcita, Patricia A. Browne, Sara H. Quach, Darin Guiney, Donald G. Doran, Kelly S. |
| description | Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood—brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis. |
| doi_str_mv | 10.1093/infdis/jiq048 |
| format | Article |
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Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood—brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis.</description><identifier>ISSN: 0022-1899</identifier><identifier>ISSN: 1537-6613</identifier><identifier>EISSN: 1537-6613</identifier><identifier>EISSN: 0022-1899</identifier><identifier>DOI: 10.1093/infdis/jiq048</identifier><identifier>PMID: 21186258</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Bacteria ; Bacterial meningitis ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Bacteriology ; Biological and medical sciences ; Blood brain barrier ; Blood-Brain Barrier - physiology ; Brain - blood supply ; Cell Line ; Central nervous system ; Chemokines ; Chemokines - genetics ; Chemokines - metabolism ; Endothelium ; Endothelium, Vascular - microbiology ; Endothelium, Vascular - physiology ; Epithelial cells ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - physiology ; Gene Expression Regulation, Bacterial ; Humans ; Infections ; Infectious diseases ; Major and Brief Reports ; Medical sciences ; Microbiology ; Miscellaneous ; Neutrophils ; Salmonella ; Salmonella typhimurium</subject><ispartof>The Journal of infectious diseases, 2011-02, Vol.203 (3), p.401-405</ispartof><rights>Copyright © 2011 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2010. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5ec3a66fa4fc405b1c2eca572c3b47c384a22e9a67c18840c9d21b875ea697693</citedby><cites>FETCH-LOGICAL-c471t-5ec3a66fa4fc405b1c2eca572c3b47c384a22e9a67c18840c9d21b875ea697693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25764858$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25764858$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,781,785,804,886,1585,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23816878$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21186258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Sorge, Nina M.</creatorcontrib><creatorcontrib>Zialcita, Patricia A.</creatorcontrib><creatorcontrib>Browne, Sara H.</creatorcontrib><creatorcontrib>Quach, Darin</creatorcontrib><creatorcontrib>Guiney, Donald G.</creatorcontrib><creatorcontrib>Doran, Kelly S.</creatorcontrib><title>Penetration and Activation of Brain Endothelium by Salmonella enterica Serovar Typhimurium</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Salmonella meningitis is a serious disease of the central nervous system, common particularly in Africa. Here, we show that Salmonella enterica serovar Typhimurium is able to adhere, invade, and penetrate human brain microvascular endothelial cells (hBMECs), the single-cell layer constituting the blood—brain barrier (BBB). Cellular invasion was dependent on host actin cytoskeleton rearrangements while expression of a functional type III secretion system was not essential. In addition, Salmonella infection activated a proinflammatory immune response targeting neutrophil signaling and recruitment. Salmonella invasion and immune activation may represent a crucial step in the penetration of the BBB and development of Salmonella meningitis.</description><subject>Bacteria</subject><subject>Bacterial meningitis</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Blood brain barrier</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Brain - blood supply</subject><subject>Cell Line</subject><subject>Central nervous system</subject><subject>Chemokines</subject><subject>Chemokines - genetics</subject><subject>Chemokines - metabolism</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - microbiology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Epithelial cells</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - physiology</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Neutrophils</subject><subject>Salmonella</subject><subject>Salmonella typhimurium</subject><issn>0022-1899</issn><issn>1537-6613</issn><issn>1537-6613</issn><issn>0022-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EokvhyBHkC4JLqL9iO5dKpSofUiWQWi5crInjsF4l9tZOVtr_Hq-yLHDiNLLm5_dm5iH0kpL3lDT8woe-8_li4x-I0I_QitZcVVJS_hitCGGsorppztCznDeEEMGleorOGKVaslqv0I9vLrgpweRjwBA6fGUnv1uesccfEviAb0IXp7Ub_Dzido_vYBhjcMMA2IXJJW8B37kUd5Dw_X679uOcCvocPelhyO7FsZ6j7x9v7q8_V7dfP325vrqtrFB0qmpnOUjZg-itIHVLLXMWasUsb4WyXAtgzDUglaVaC2KbjtFWq9qBbJRs-Dm6XHS3czu6zpaZEgxmm_wIaW8iePNvJ_i1-Rl3hhNFKeFF4O1RIMWH2eXJjD7bw37BxTkbzVi5IdGikNVC2hRzTq4_uVBiDnGYJQ6zxFH413-PdqJ_378Ab44AZAtDnyDY8v3EcU2lVgfu3cLFeftfz1cLuslTTH-kaiWFLpa_AHgNrv8</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>van Sorge, Nina M.</creator><creator>Zialcita, Patricia A.</creator><creator>Browne, Sara H.</creator><creator>Quach, Darin</creator><creator>Guiney, Donald G.</creator><creator>Doran, Kelly S.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110201</creationdate><title>Penetration and Activation of Brain Endothelium by Salmonella enterica Serovar Typhimurium</title><author>van Sorge, Nina M. ; Zialcita, Patricia A. ; Browne, Sara H. ; Quach, Darin ; Guiney, Donald G. ; Doran, Kelly S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5ec3a66fa4fc405b1c2eca572c3b47c384a22e9a67c18840c9d21b875ea697693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bacteria</topic><topic>Bacterial meningitis</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Blood brain barrier</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Brain - blood supply</topic><topic>Cell Line</topic><topic>Central nervous system</topic><topic>Chemokines</topic><topic>Chemokines - genetics</topic><topic>Chemokines - metabolism</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - microbiology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Epithelial cells</topic><topic>Fundamental and applied biological sciences. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Bacteria Bacterial meningitis Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Blood brain barrier Blood-Brain Barrier - physiology Brain - blood supply Cell Line Central nervous system Chemokines Chemokines - genetics Chemokines - metabolism Endothelium Endothelium, Vascular - microbiology Endothelium, Vascular - physiology Epithelial cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Gene Expression Regulation, Bacterial Humans Infections Infectious diseases Major and Brief Reports Medical sciences Microbiology Miscellaneous Neutrophils Salmonella Salmonella typhimurium |
| title | Penetration and Activation of Brain Endothelium by Salmonella enterica Serovar Typhimurium |
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