Sensitization of cells overexpressing multidrug-resistant proteins by pluronic P85

This study evaluated the chemosensitizing effects of Pluronic P85 (P85) on cells expressing multidrug resistance-associated proteins, MRPI and MRP2. Cell models included MRP1- and MRP2-transfected MDCKII cells as well as doxorubicin-selected COR-L23/R cells overexpressing MRP1. Effects of P85 on cel...

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Veröffentlicht in:	Pharmaceutical research 2003-10, Vol.20 (10), p.1581-1590
Hauptverfasser:	BATRAKOVA, Elena V, SHU LI, ALAKHOV, Valery Yu, ELMQUIST, William F, MILLER, Donald W, KABANOV, Alexander V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - biosynthesis Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Blotting, Western Cell Line Cell Membrane - chemistry Cell Membrane - drug effects Cytotoxicity Doxorubicin - pharmacology Drug Resistance, Multiple - drug effects General aspects Glutathione - metabolism Glycoproteins Humans Medical sciences Membrane Transport Proteins - metabolism Multidrug Resistance-Associated Proteins - metabolism Pharmacology. Drug treatments Poloxamer - pharmacology Potassium Proteins Time Factors Tumors Vinblastine - pharmacology Viscosity
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