Phosphoproteomic Analysis of Signaling Pathways in Head and Neck Squamous Cell Carcinoma Patient Samples

Molecular targeted therapy represents a promising new strategy for treating cancers because many small-molecule inhibitors targeting protein kinases have recently become available. Reverse-phase protein microarrays (RPPAs) are a useful platform for identifying dysregulated signaling pathways in tumo...

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Veröffentlicht in:	The American journal of pathology 2011-02, Vol.178 (2), p.548-571
Hauptverfasser:	Frederick, Mitchell J, VanMeter, Amy J, Gadhikar, Mayur A, Henderson, Ying C, Yao, Hui, Pickering, Curtis C, Williams, Michelle D, El-Naggar, Adel K, Sandulache, Vlad, Tarco, Emily, Myers, Jeffrey N, Clayman, Gary L, Liotta, Lance A, Petricoin, Emanuel F, Calvert, Valerie S, Fodale, Valentina, Wang, Jing, Weber, Randal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - metabolism Blotting, Western Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cluster Analysis Female Head and Neck Neoplasms - enzymology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mucous Membrane - metabolism Mucous Membrane - pathology Neoplasm Proteins - metabolism Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphoproteins - metabolism Phosphorylation Protein Array Analysis Protein Kinase C - metabolism Proteomics - methods Regular Reproducibility of Results Signal Transduction Tumors
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