TGF-β1 promotes motility and invasiveness of glioma cells through activation of ADAM17

The transforming growth factor β1 (TGF-β1) belongs to a family of structurally related polypeptide factors. TGF-beta plays an important role in the pathobiology of invasion of malignant gliomas. The objective of the present study was to investigate the impact of TNF-α converting enzyme (TACE/ADAM17)...

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Veröffentlicht in:	Oncology reports 2011-05, Vol.25 (5), p.1329-1335
Hauptverfasser:	YONG LU, FENG JIANG, XUGUANG ZHENG, KATAKOWSKI, Mark, BULLER, Benjamin, TONY TO, Shing-Shun, CHOPP, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM Proteins - metabolism ADAM17 Protein Benzamides - pharmacology Biological and medical sciences Cell Line, Tumor Cell Movement - drug effects Dioxoles - pharmacology Enzyme Activation - drug effects Gene Expression Regulation, Neoplastic - drug effects Glioma - genetics Glioma - metabolism Humans Medical sciences Neoplasm Invasiveness Neurology RNA, Messenger - genetics Signal Transduction - drug effects Transforming Growth Factor beta1 - antagonists & inhibitors Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Tumors Tumors of the nervous system. Phacomatoses
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