HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

Background The P140 phosphopeptide issued from the spliceosomal U1-70K small nuclear ribonucleoprotein protein displays protective properties in MRL/lpr lupus-prone mice. It binds both major histocompatibility class II (MHCII) and HSC70/Hsp73 molecules. P140 peptide increases MRL/lpr peripheral bloo...

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Veröffentlicht in:	Annals of the rheumatic diseases 2011-05, Vol.70 (5), p.837-843
Hauptverfasser:	Page, Nicolas, Gros, Frédéric, Schall, Nicolas, Décossas, Marion, Bagnard, Dominique, Briand, Jean-Paul, Muller, Sylviane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - drug effects Apoptosis Autophagy Autophagy - drug effects B-Lymphocytes - pathology Basic and Translational Research Biological and medical sciences Dermatology Diseases of the osteoarticular system Experiments Histocompatibility Antigens Class II - drug effects Histocompatibility Antigens Class II - metabolism HSC70 Heat-Shock Proteins - antagonists & inhibitors HSC70 Heat-Shock Proteins - metabolism Immunoglobulins Immunology Immunotherapy Life Sciences Lupus Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymphocytes Medical sciences Mice Mice, Inbred MRL lpr Peptide Fragments - pharmacokinetics Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Peptides Signal Transduction - drug effects Skin involvement in other diseases. Miscellaneous. General aspects Studies Tissue Distribution
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