Endothelial Nitric Oxide Synthase Overexpression Restores the Efficiency of Bone Marrow Mononuclear Cell-Based Therapy

Bone marrow-derived mononuclear cells (BMMNCs) enhance postischemic neovascularization, and their therapeutic use is currently under clinical investigation. However, cardiovascular risk factors, including diabetes mellitus and hypercholesterolemia, lead to the abrogation of BMMNCs proangiogenic pote...

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Veröffentlicht in:	The American journal of pathology 2011, Vol.178 (1), p.55-60
Hauptverfasser:	Mees, Barend, Récalde, Alice, Loinard, Céline, Tempel, Dennie, Godinho, Marcia, Vilar, José, van Haperen, Rien, Lévy, Bernard, de Crom, Rini, Silvestre, Jean-Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Atherosclerosis - physiopathology Atherosclerosis - therapy Biological and medical sciences Genetic Therapy - methods Hindlimb - blood supply Humans Investigative techniques, diagnostic techniques (general aspects) Ischemia - therapy Medical sciences Mice Mice, Knockout Mice, Transgenic Monocytes - enzymology Monocytes - transplantation Neovascularization, Physiologic - genetics Nitric Oxide Synthase Type III - genetics Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Short Communication
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