Designed Reduction of "Streptococcus pneumoniae" Pathogenicity via Synthetic Changes in Virulence Factor Codon-pair Bias

In this study, we used a previously described method of controlling gene expression with computer-based gene design and de novo DNA synthesis to attenuate the virulence of Streptococcus pneumoniae. We produced 2 S. pneumoniae serotype 3 (SP3) strains in which the pneumolysin gene (ply) was recoded w...

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Veröffentlicht in:	The Journal of infectious diseases 2011-05, Vol.203 (9), p.1264-1273
Hauptverfasser:	Coleman, J. Robert, Papamichail, Dimitris, Yano, Masahide, del Mar García-Suárez, María, Pirofski, Liise-anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B lymphocytes BACTERIA Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Codon - genetics Codons Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Gene Expression Infections Infectious diseases Interleukins Lung - microbiology Lung - pathology Major and Brief Reports Medical sciences Mice Mice, Inbred BALB C Microbiology Miscellaneous Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - pathology Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - pathogenicity Streptolysins - genetics Streptolysins - metabolism T lymphocytes Vaccination Virulence Virulence Factors - genetics Virulence Factors - metabolism
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