Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

Flavopiridol is a protein bound, cytotoxic, cyclin-dependent kinase inhibitor. Flavopiridol given by 1-hour bolus at 50 mg/m2 daily 3 times followed by cytosine arabinoside and mitoxantrone (FLAM) is active in adults with poor-risk acute leukemias. A pharmacologically derived “hybrid” schedule (30-m...

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Veröffentlicht in:	Blood 2011-03, Vol.117 (12), p.3302-3310
Hauptverfasser:	Karp, Judith E., Smith, B. Douglas, Resar, Linda S., Greer, Jacqueline M., Blackford, Amanda, Zhao, Ming, Moton-Nelson, Dwella, Alino, Katrina, Levis, Mark J., Gore, Steven D., Joseph, Biju, Carraway, Hetty, McDevitt, Michael A., Bagain, Lorena, Mackey, Karen, Briel, Janet, Doyle, L. Austin, Wright, John J., Rudek, Michelle A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy, Adjuvant Clinical Trials and Observations Cytarabine - administration & dosage Cytarabine - pharmacokinetics Dose-Response Relationship, Drug Drug Administration Schedule Female Flavonoids - administration & dosage Flavonoids - pharmacokinetics Hematologic and hematopoietic diseases Humans Infusion Pumps Leukemia - drug therapy Leukemia - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Mitoxantrone - administration & dosage Mitoxantrone - pharmacokinetics Piperidines - administration & dosage Piperidines - pharmacokinetics Young Adult
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