Distamycin A and tallimustine inhibit TBP binding and basal in vitro transcription

The antibiotic distamycin A is a DNA minor groove binding drug (MGB) that recognizes a stretch of a least four ATs. The alkylating benzoyl mustard derivative tallimustine (FCE 24517) has powerfull anti-tumor activity. Using the electrophoretic mobility shift assay (EMSA) we determined that both comp...

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Veröffentlicht in:	Nucleic acids research 1995-05, Vol.23 (10), p.1657-1663
Hauptverfasser:	Bellorini, Marianna, Moncollin, Vincent, D'lncalci, Maurizio, Mongelli, Nicola, Mantovani, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Base Sequence Biochemistry, Molecular Biology Distamycins - pharmacology DNA-Binding Proteins - drug effects DNA-Binding Proteins - isolation & purification DNA-Binding Proteins - metabolism Humans Intercalating Agents - pharmacology Life Sciences Molecular Sequence Data Nitrogen Mustard Compounds - pharmacology Oligodeoxyribonucleotides Recombinant Proteins - metabolism Saccharomyces cerevisiae - metabolism TATA Box TATA-Box Binding Protein Transcription Factor TFIIA Transcription Factor TFIIB Transcription Factors - drug effects Transcription Factors - isolation & purification Transcription Factors - metabolism Transcription, Genetic - drug effects
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