Inhibition of HIV-1 reverse transcription by triple-helix forming oligonucleotides with viral RNA

ABSRACT Reverse transcription of retroviral RNA into doublestranded DNA is catalyzed by reverse transcriptase (RT). A highly conserved polypurine tract (PPT) on the viral RNA serves as primer for plus-strand DNA synthesis and is a possible target for triple-helix formation. Triple-helix formation du...

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Veröffentlicht in:	Nucleic acids research 1995-04, Vol.23 (7), p.1204-1212
Hauptverfasser:	Volkmann, Silke, Jendis, Jörg, Frauendorf, Albrecht, Moelling, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemistry Antiviral Agents - pharmacology Base Sequence Cell Line Cell Transformation, Viral HIV Reverse Transcriptase HIV-1 - drug effects HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans In Vitro Techniques Models, Biological Molecular Sequence Data Nucleic Acid Conformation Oligonucleotides - chemistry Oligonucleotides - genetics Oligonucleotides - pharmacology Ribonuclease H RNA, Viral - genetics RNA, Viral - metabolism RNA, Viral - pharmacology RNA-Directed DNA Polymerase - genetics Transcription, Genetic Virus Replication - drug effects
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