Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle
Bovines present contrasting, heritable phenotypes of infestations with the cattle tick, Rhipicephalus ( Boophilus) microplus . Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that...
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| Veröffentlicht in: | Immunogenetics (New York) 2011-05, Vol.63 (5), p.319-324 |
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| creator | Carvalho, Wanessa Araújo Ianella, Patricia Arnoldi, Frederico G. C. Caetano, Alexandre Rodrigues Maruyama, Sandra Regina Ferreira, Beatriz Rossetti Andreucci Conti, Luís Henrique da Silva, Marcia Ramos Monteiro Paula, José Otavio F. Maia, Antonio Augusto Mendes de Miranda Santos, Isabel K. Ferreira |
| description | Bovines present contrasting, heritable phenotypes of infestations with the cattle tick,
Rhipicephalus (
Boophilus)
microplus
. Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that occur in the constant region of IgG may differ in their capacity to bind with tick IGBPs; this may be reflected by the distribution of distinct allotypes according to phenotypes of tick infestations. In order to test this hypothesis, we investigated the frequency of haplotypes of bovine IgG2 among tick-resistant and tick-susceptible breeds of bovines. Sequencing of the gene coding for the heavy chain of IgG2 from 114 tick-resistant (
Bos taurus indicus
, Nelore breed) and tick-susceptible (
B. t. taurus
, Holstein breed) bovines revealed SNPs that generated 13 different haplotypes, of which 11 were novel and 5 were exclusive of Holstein and 3 of Nelore breeds. Alignment and modeling of coded haplotypes for hinge regions of the bovine IgG2 showed that they differ in the distribution of polar and hydrophobic amino acids and in shape according to the distribution of these amino acids. We also found that there was an association between genotypes of the constant region of the IgG2 heavy chain with phenotypes of tick infestations. These findings open the possibility of investigating if certain IgG allotypes hinder the function of tick IGBPs. If so, they may be markers for breeding for resistance against tick infestations. |
| doi_str_mv | 10.1007/s00251-011-0515-y |
| format | Article |
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Rhipicephalus (
Boophilus)
microplus
. Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that occur in the constant region of IgG may differ in their capacity to bind with tick IGBPs; this may be reflected by the distribution of distinct allotypes according to phenotypes of tick infestations. In order to test this hypothesis, we investigated the frequency of haplotypes of bovine IgG2 among tick-resistant and tick-susceptible breeds of bovines. Sequencing of the gene coding for the heavy chain of IgG2 from 114 tick-resistant (
Bos taurus indicus
, Nelore breed) and tick-susceptible (
B. t. taurus
, Holstein breed) bovines revealed SNPs that generated 13 different haplotypes, of which 11 were novel and 5 were exclusive of Holstein and 3 of Nelore breeds. Alignment and modeling of coded haplotypes for hinge regions of the bovine IgG2 showed that they differ in the distribution of polar and hydrophobic amino acids and in shape according to the distribution of these amino acids. We also found that there was an association between genotypes of the constant region of the IgG2 heavy chain with phenotypes of tick infestations. These findings open the possibility of investigating if certain IgG allotypes hinder the function of tick IGBPs. If so, they may be markers for breeding for resistance against tick infestations.</description><identifier>ISSN: 0093-7711</identifier><identifier>EISSN: 1432-1211</identifier><identifier>DOI: 10.1007/s00251-011-0515-y</identifier><identifier>PMID: 21301827</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Allergology ; Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Biomedical and Life Sciences ; Biomedicine ; Boophilus microplus ; Bos taurus ; Brief Communication ; Cattle ; Cattle - genetics ; Cattle - immunology ; Cattle Diseases - genetics ; Cattle Diseases - immunology ; Cattle Diseases - parasitology ; Cell Biology ; Ectoparasites ; Gene Function ; Genetic Predisposition to Disease ; Genotypes ; Haplotypes ; Human Genetics ; Immunoglobulin gamma-Chains - genetics ; Immunoglobulin Heavy Chains - genetics ; Immunoglobulins ; Immunology ; Ixodidae ; Male ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Rhipicephalus ; Salivary Glands - immunology ; Tick Infestations - genetics ; Tick Infestations - immunology ; Tick Infestations - veterinary ; Ticks - immunology</subject><ispartof>Immunogenetics (New York), 2011-05, Vol.63 (5), p.319-324</ispartof><rights>The Author(s) 2011</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-279dcbf22b229297ab890474327fdeb29bab2bed6f5e348a82fd3c54866429103</citedby><cites>FETCH-LOGICAL-c500t-279dcbf22b229297ab890474327fdeb29bab2bed6f5e348a82fd3c54866429103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00251-011-0515-y$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00251-011-0515-y$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21301827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carvalho, Wanessa Araújo</creatorcontrib><creatorcontrib>Ianella, Patricia</creatorcontrib><creatorcontrib>Arnoldi, Frederico G. C.</creatorcontrib><creatorcontrib>Caetano, Alexandre Rodrigues</creatorcontrib><creatorcontrib>Maruyama, Sandra Regina</creatorcontrib><creatorcontrib>Ferreira, Beatriz Rossetti</creatorcontrib><creatorcontrib>Andreucci Conti, Luís Henrique</creatorcontrib><creatorcontrib>da Silva, Marcia Ramos Monteiro</creatorcontrib><creatorcontrib>Paula, José Otavio F.</creatorcontrib><creatorcontrib>Maia, Antonio Augusto Mendes</creatorcontrib><creatorcontrib>de Miranda Santos, Isabel K. Ferreira</creatorcontrib><title>Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle</title><title>Immunogenetics (New York)</title><addtitle>Immunogenetics</addtitle><addtitle>Immunogenetics</addtitle><description>Bovines present contrasting, heritable phenotypes of infestations with the cattle tick,
Rhipicephalus (
Boophilus)
microplus
. Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that occur in the constant region of IgG may differ in their capacity to bind with tick IGBPs; this may be reflected by the distribution of distinct allotypes according to phenotypes of tick infestations. In order to test this hypothesis, we investigated the frequency of haplotypes of bovine IgG2 among tick-resistant and tick-susceptible breeds of bovines. Sequencing of the gene coding for the heavy chain of IgG2 from 114 tick-resistant (
Bos taurus indicus
, Nelore breed) and tick-susceptible (
B. t. taurus
, Holstein breed) bovines revealed SNPs that generated 13 different haplotypes, of which 11 were novel and 5 were exclusive of Holstein and 3 of Nelore breeds. Alignment and modeling of coded haplotypes for hinge regions of the bovine IgG2 showed that they differ in the distribution of polar and hydrophobic amino acids and in shape according to the distribution of these amino acids. We also found that there was an association between genotypes of the constant region of the IgG2 heavy chain with phenotypes of tick infestations. These findings open the possibility of investigating if certain IgG allotypes hinder the function of tick IGBPs. If so, they may be markers for breeding for resistance against tick infestations.</description><subject>Allergology</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Boophilus microplus</subject><subject>Bos taurus</subject><subject>Brief Communication</subject><subject>Cattle</subject><subject>Cattle - genetics</subject><subject>Cattle - immunology</subject><subject>Cattle Diseases - genetics</subject><subject>Cattle Diseases - immunology</subject><subject>Cattle Diseases - parasitology</subject><subject>Cell Biology</subject><subject>Ectoparasites</subject><subject>Gene Function</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Immunoglobulin gamma-Chains - genetics</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Ixodidae</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Rhipicephalus</subject><subject>Salivary Glands - immunology</subject><subject>Tick Infestations - genetics</subject><subject>Tick Infestations - immunology</subject><subject>Tick Infestations - veterinary</subject><subject>Ticks - immunology</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkV9r3iAUh2WsrO_afYDdjLCbXWXTY0zizWCUrS0UdtNei5qTvOmSmKl5Id--vkvX_YExUATP46PHHyGvGX3PKK0-BEpBsJyyNAUT-fqM7FjBIWfA2HOyo1TyvKoYOyUvQ7inlAkJ5QtyCoxTVkO1I92VngcX1xlD5tos7jEz7tBPmF13l5DtUR_WrNPjqDO71_2UpRF7-y33GPoQ9RQzPTXbVliCxTn2ZkgSj9j8UFod44Dn5KTVQ8BXj-sZufvy-fbiKr_5enl98ekmt4LSmEMlG2taAAMgQVba1JIWVeqpahs0II02YLApW4G8qHUNbcOtKOqyLEAyys_Ix807L2bExuIUvR7U7PtR-1U53as_K1O_V507KE7LGkSZBO8eBd59XzBENfaprWHQE7olKEmBi4LX_L9kLWRVJKtM5Nu_yHu3-Cn9wxHiIIriqGMbZL0LwWP79GhG1TFutcWtUtzqGLda05k3v3f7dOJnvgmADQipNHXof938b-sDKay2Rw</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Carvalho, Wanessa Araújo</creator><creator>Ianella, Patricia</creator><creator>Arnoldi, Frederico G. C.</creator><creator>Caetano, Alexandre Rodrigues</creator><creator>Maruyama, Sandra Regina</creator><creator>Ferreira, Beatriz Rossetti</creator><creator>Andreucci Conti, Luís Henrique</creator><creator>da Silva, Marcia Ramos Monteiro</creator><creator>Paula, José Otavio F.</creator><creator>Maia, Antonio Augusto Mendes</creator><creator>de Miranda Santos, Isabel K. 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C. ; Caetano, Alexandre Rodrigues ; Maruyama, Sandra Regina ; Ferreira, Beatriz Rossetti ; Andreucci Conti, Luís Henrique ; da Silva, Marcia Ramos Monteiro ; Paula, José Otavio F. ; Maia, Antonio Augusto Mendes ; de Miranda Santos, Isabel K. 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C.</au><au>Caetano, Alexandre Rodrigues</au><au>Maruyama, Sandra Regina</au><au>Ferreira, Beatriz Rossetti</au><au>Andreucci Conti, Luís Henrique</au><au>da Silva, Marcia Ramos Monteiro</au><au>Paula, José Otavio F.</au><au>Maia, Antonio Augusto Mendes</au><au>de Miranda Santos, Isabel K. Ferreira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle</atitle><jtitle>Immunogenetics (New York)</jtitle><stitle>Immunogenetics</stitle><addtitle>Immunogenetics</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>63</volume><issue>5</issue><spage>319</spage><epage>324</epage><pages>319-324</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><abstract>Bovines present contrasting, heritable phenotypes of infestations with the cattle tick,
Rhipicephalus (
Boophilus)
microplus
. Tick salivary glands produce IgG-binding proteins (IGBPs) as a mechanism for escaping from host antibodies that these ectoparasites ingest during blood meals. Allotypes that occur in the constant region of IgG may differ in their capacity to bind with tick IGBPs; this may be reflected by the distribution of distinct allotypes according to phenotypes of tick infestations. In order to test this hypothesis, we investigated the frequency of haplotypes of bovine IgG2 among tick-resistant and tick-susceptible breeds of bovines. Sequencing of the gene coding for the heavy chain of IgG2 from 114 tick-resistant (
Bos taurus indicus
, Nelore breed) and tick-susceptible (
B. t. taurus
, Holstein breed) bovines revealed SNPs that generated 13 different haplotypes, of which 11 were novel and 5 were exclusive of Holstein and 3 of Nelore breeds. Alignment and modeling of coded haplotypes for hinge regions of the bovine IgG2 showed that they differ in the distribution of polar and hydrophobic amino acids and in shape according to the distribution of these amino acids. We also found that there was an association between genotypes of the constant region of the IgG2 heavy chain with phenotypes of tick infestations. These findings open the possibility of investigating if certain IgG allotypes hinder the function of tick IGBPs. If so, they may be markers for breeding for resistance against tick infestations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21301827</pmid><doi>10.1007/s00251-011-0515-y</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Immunogenetics (New York), 2011-05, Vol.63 (5), p.319-324 |
| issn | 0093-7711 1432-1211 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Allergology Amino Acid Sequence Amino acids Animals Base Sequence Biomedical and Life Sciences Biomedicine Boophilus microplus Bos taurus Brief Communication Cattle Cattle - genetics Cattle - immunology Cattle Diseases - genetics Cattle Diseases - immunology Cattle Diseases - parasitology Cell Biology Ectoparasites Gene Function Genetic Predisposition to Disease Genotypes Haplotypes Human Genetics Immunoglobulin gamma-Chains - genetics Immunoglobulin Heavy Chains - genetics Immunoglobulins Immunology Ixodidae Male Molecular Sequence Data Polymorphism, Single Nucleotide Rhipicephalus Salivary Glands - immunology Tick Infestations - genetics Tick Infestations - immunology Tick Infestations - veterinary Ticks - immunology |
| title | Haplotypes of the bovine IgG2 heavy gamma chain in tick-resistant and tick-susceptible breeds of cattle |
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