A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese

A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance,...

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Veröffentlicht in:	The Journal of infectious diseases 2011-04, Vol.203 (7), p.943-947
Hauptverfasser:	An, Ping, Winkler, Cheryl, Guan, Li, O'Brien, Stephen J., Zeng, Zheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asian Continental Ancestry Group Biological and medical sciences China Chronic hepatitis Cirrhosis Female Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B virus Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Hepatitis B, Chronic - genetics Hepatitis B, Chronic - immunology Hepatocellular carcinoma HLA antigens HLA-DP alpha-Chains HLA-DP Antigens - genetics HLA-DP Antigens - immunology Humans Immunity, Innate Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Miscellaneous Polymorphism, Single Nucleotide Vaccination Viral Load Virology Viruses
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