A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese
A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance,...
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| Veröffentlicht in: | The Journal of infectious diseases 2011-04, Vol.203 (7), p.943-947 |
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| container_title | The Journal of infectious diseases |
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| creator | An, Ping Winkler, Cheryl Guan, Li O'Brien, Stephen J. Zeng, Zheng |
| description | A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA -DP Al rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P = .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma. |
| doi_str_mv | 10.1093/infdis/jiq154 |
| format | Article |
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We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA -DP Al rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P = .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiq154</identifier><identifier>PMID: 21402545</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Asian Continental Ancestry Group ; Biological and medical sciences ; China ; Chronic hepatitis ; Cirrhosis ; Female ; Fundamental and applied biological sciences. Psychology ; Hepatitis ; Hepatitis B virus ; Hepatitis B virus - immunology ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - immunology ; Hepatocellular carcinoma ; HLA antigens ; HLA-DP alpha-Chains ; HLA-DP Antigens - genetics ; HLA-DP Antigens - immunology ; Humans ; Immunity, Innate ; Infections ; Infectious diseases ; Major and Brief Reports ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Polymorphism, Single Nucleotide ; Vaccination ; Viral Load ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2011-04, Vol.203 (7), p.943-947</ispartof><rights>Copyright © 2011 Oxford University Press</rights><rights>The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-986725dae05998c570403001751e31f4caf5b2490c2e3013e99c9315e0d0f8ba3</citedby><cites>FETCH-LOGICAL-c570t-986725dae05998c570403001751e31f4caf5b2490c2e3013e99c9315e0d0f8ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41151036$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41151036$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,1584,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24085393$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21402545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>An, Ping</creatorcontrib><creatorcontrib>Winkler, Cheryl</creatorcontrib><creatorcontrib>Guan, Li</creatorcontrib><creatorcontrib>O'Brien, Stephen J.</creatorcontrib><creatorcontrib>Zeng, Zheng</creatorcontrib><creatorcontrib>HBV Study Consortium</creatorcontrib><creatorcontrib>HBV Study Consortium</creatorcontrib><creatorcontrib>the HBV Study Consortium</creatorcontrib><title>A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A recent genome-wide study showed that the single nucleotide polymorphisms (SNPs) in the HLA-DP region were associated with chronic hepatitis virus (HBV) infection in Japanese and Thai persons. We tested the effects of HLA-DP SNPs for all major HBV outcomes in Han Chinese (n = 1742): HBV resistance, clearance, chronic infection, cirrhosis, and hepatocellular carcinoma. HLA -DP Al rs3077 T was strongly associated with decreased risk of chronic HBV infection (odds ratio, .62; P = .001), consistent with the previous report. We showed for the first time to our knowledge that it is a predictor for HBV clearance (odds ratio, 2.41; P = .001). However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Chronic hepatitis</subject><subject>Cirrhosis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - genetics</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatocellular carcinoma</subject><subject>HLA antigens</subject><subject>HLA-DP alpha-Chains</subject><subject>HLA-DP Antigens - genetics</subject><subject>HLA-DP Antigens - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Vaccination</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9v0zAUB3ALMbEyOHIEWZMQXMKe4x-JL0glgxWpCA6wq3HTF-YqsTs7QeK_J1FK2S5wsvT88fOzv4Q8Y_CGgeYXzjdbly527pZJ8YAsmORFphTjD8kCIM8zVmp9Sh6ntAMAwVXxiJzmTEAuhVyQ70taha4Lnp6v1svs8suSndNrG531PXWJWvrJ7kKkl9hj7JyfyqGhK9zb3vUjeEevXRwSrVq00foaqfN0ZT2tbpzHhE_ISWPbhE8P6xn59uH912qVrT9ffayW66yWBfSZLlWRy61FkFqXU00AB2CFZMhZI2rbyE0uNNQ5cmActa41ZxJhC025sfyMvJ377odNh9safR9ta_bRdTb-MsE6c3_HuxvzI_w0HFQJnI8NXh0axHA7YOpN51KNbWs9hiGZUvFCFRJglK__KZmSQmmmxNQ0m2kdQ0oRm-NADMyUn5nzM3N-o39x9xVH_SewEbw8AJtq2zbTl4_Hj05AKbnmf2cMw_6_dz6f6S71IR6xYEwy4Ir_Bt-zueI</recordid><startdate>20110401</startdate><enddate>20110401</enddate><creator>An, Ping</creator><creator>Winkler, Cheryl</creator><creator>Guan, Li</creator><creator>O'Brien, Stephen J.</creator><creator>Zeng, Zheng</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110401</creationdate><title>A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese</title><author>An, Ping ; Winkler, Cheryl ; Guan, Li ; O'Brien, Stephen J. ; Zeng, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-986725dae05998c570403001751e31f4caf5b2490c2e3013e99c9315e0d0f8ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Chronic hepatitis</topic><topic>Cirrhosis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Asian Continental Ancestry Group Biological and medical sciences China Chronic hepatitis Cirrhosis Female Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B virus Hepatitis B virus - immunology Hepatitis B virus - isolation & purification Hepatitis B, Chronic - genetics Hepatitis B, Chronic - immunology Hepatocellular carcinoma HLA antigens HLA-DP alpha-Chains HLA-DP Antigens - genetics HLA-DP Antigens - immunology Humans Immunity, Innate Infections Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Middle Aged Miscellaneous Polymorphism, Single Nucleotide Vaccination Viral Load Virology Viruses |
| title | A Common "HLA-DPA1" Variant is a Major Determinant of Hepatitis B Virus Clearance in Han Chinese |
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