Novel Jojoba Oil-Based Emulsion Gel Formulations for Clotrimazole Delivery

Jojoba oil-based emulgel formulations were prepared using different concentrations of various gelling agents, such as hydroxypropyl methylcellulose (HPMC) and Carbopol 934 P and combination of both. The prepared emulgels were physically evaluated for their stability after temperature cycle test, cen...

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Veröffentlicht in:AAPS PharmSciTech 2011-03, Vol.12 (1), p.239-247
Hauptverfasser: Shahin, Mostafa, Abdel Hady, Seham, Hammad, Mohammed, Mortada, Nahed
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creator Shahin, Mostafa
Abdel Hady, Seham
Hammad, Mohammed
Mortada, Nahed
description Jojoba oil-based emulgel formulations were prepared using different concentrations of various gelling agents, such as hydroxypropyl methylcellulose (HPMC) and Carbopol 934 P and combination of both. The prepared emulgels were physically evaluated for their stability after temperature cycle test, centrifugation and long-term shelf storage for 1 year at room temperature. The in vitro release at 37°C was studied to define the effect of the concentration and type of the gelling agent. A comparison between the formulated emulgels and two commercially available products, Candistan® and Canesten® creams, was carried out to judge their efficacy and stability. The prepared emulgels exhibited non-Newtonian shear thinning behavior with little or no thixotropy. Four emulgels showed excellent stability as they demonstrated consistent rheological model under different treatment conditions. The in vitro release test showed variation in the extent of percent drug released. The drug release from the commercial preparation was lower than some of the prepared emulgel formulae. One formula containing combination of the two gelling agents (HPMC and Carbopol 934 P), showed excellent stability and high extent of clotrimazole release was microbiologically evaluated against Candida albicans using cylinder and plate method. The selected formula showed superior antimycotic activity compared to the commercially available formulation. Further in vivo animal studies for the obtained stable formula is recommended.
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One formula containing combination of the two gelling agents (HPMC and Carbopol 934 P), showed excellent stability and high extent of clotrimazole release was microbiologically evaluated against Candida albicans using cylinder and plate method. The selected formula showed superior antimycotic activity compared to the commercially available formulation. 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One formula containing combination of the two gelling agents (HPMC and Carbopol 934 P), showed excellent stability and high extent of clotrimazole release was microbiologically evaluated against Candida albicans using cylinder and plate method. The selected formula showed superior antimycotic activity compared to the commercially available formulation. 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subjects Acrylates - chemistry
Administration, Topical
Antifungal Agents - administration & dosage
Antifungal Agents - chemistry
Antifungal Agents - pharmacokinetics
Antifungal Agents - pharmacology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Candida albicans - drug effects
Clotrimazole - administration & dosage
Clotrimazole - chemistry
Clotrimazole - pharmacokinetics
Clotrimazole - pharmacology
Dosage Forms
Drug Delivery Systems
Drug Stability
Emulsions
Excipients - chemistry
Gels
Humans
Hypromellose Derivatives
Indexing in process
Methylcellulose - analogs & derivatives
Methylcellulose - chemistry
Pharmacology/Toxicology
Pharmacy
Research Article
Viscosity
Waxes - chemistry
title Novel Jojoba Oil-Based Emulsion Gel Formulations for Clotrimazole Delivery
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