Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth

The proliferation cell nuclear antigen (PCNA) is a critical protein required for DNA replication in proliferating cells including cancer cells. However, direct inhibition of PCNA in cancer cells has been difficult due to the lack of targetable sites. We previously reported that phosphorylation of ty...

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Veröffentlicht in:	Molecular cancer therapeutics 2011-01, Vol.10 (1), p.29-36
Hauptverfasser:	Zhao, Huajun, Lo, Yuan-Hung, Ma, Li, Waltz, Susan E, Gray, Jerilyn K, Hung, Mien-Chie, Wang, Shao-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Growth Processes - drug effects Cell Line, Tumor Cell Survival - drug effects Humans Immunohistochemistry Male Mice Mice, Nude Molecular Sequence Data Molecular Targeted Therapy Peptides - pharmacology Phosphorylation - drug effects Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Tyrosine - metabolism Xenograft Model Antitumor Assays
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